Cord Blood News

Researchers developed a system to quantify Y chromosome gain or loss in patient-derived prostate cancer organoids. Using this system, they observed Y chromosome loss...

[Cell Death & Disease] Investigators reported a differentiation system toward enterocytes and goblet cells, the two major colonic epithelial cell lineages, using colon organoids generated from healthy tissue of colorectal cancer patients.

[Oncogene] Using prostate organoid models, scientists showed that either Bzw2 downregulation or EIF5A2 overexpression leads to increased organoid size and in vivo prostate growth.

[JCI Insight] Using primary intestinal organoids and air-liquid interface cultures of airway epithelia, scientists demonstrated that the F508del mutation in ferret CF transmembrane conductance regulator (CFTR) results in a severe folding and trafficking defect, which could be partially restored by treatment with CFTR modulators.

[Journal Of Experimental & Clinical Cancer Research] Colorectal cancer (CRC) cell xenografts, patient-derived xenografts, patient-derived organoids, and orthotopic metastasis mouse models were utilized to determine the in vivo role of SF3B3 in CRC progression and metastasis.

[Cell Death & Disease] Scientists generated self-organizing heart organoids using human-induced pluripotent stem cells. These organoids consisted of cardiomyocytes, fibroblasts, and endothelial cells, mimicking the cellular composition of the human heart.

[Signal Transduction And Targeted Therapy] The authors outline key developments in the induced pluripotent stem cell (iPSC) field and highlight the immense versatility of the iPSC technology for in vitro modeling and therapeutic applications.

[Drug Target Review] Scientists at the Organoid group have developed a new organoid model derived from thymic epithelial cells (TECs) that can be used to study the thymus. This is the first laboratory model that enables long-term culture of TECs, presenting new opportunities to study their function.

[Nature Communications] Researchers described a case of gene therapy-related T cell acute lymphoblastic leukemia that developed 4.7 years after treatment. The patient underwent chemotherapy and haploidentical transplantation and is currently in remission.

[Cell Reports] Scientists showed that clusters of the peri-synaptic ECM, recognized by CS56 antibody, emerged in response to sensory stimuli, showing temporal and spatial coincidence with dendritic spine plasticity.

[Luxa Biotechnology] Luxa Biotechnology has been awarded a $4 million grant from the California Institute for Regeneration Medicine, supporting its ongoing Phase I/IIa clinical study of the RPESC-RPE-4W cell transplantation for the treatment of dry age-related macular degeneration (AMD).

[Nature] The authors uncovered a novel ANXA2+ migratory hepatocyte subpopulation, which emerged during human liver regeneration, and a corollary subpopulation in a mouse model of acetaminophen-induced liver regeneration.