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Cell Therapy News is an online resource dedicated to sharing the latest cell therapy, gene therapy, and regenerative medicine research.
Engineered CD47 Protects T Cells for Enhanced Antitumour Immunity
[Nature] Researchers administered anti-CD47 antibodies in combination with adoptively transferred T cells with the goal of enhancing antitumour efficacy but observed abrogated therapeutic benefit due to rapid macrophage-mediated clearance of T cells expressing CARs or engineered T cell receptors.
CAR T Cell Membrane Camouflaged Nanocatalyst Augments CAR T Cell Therapy Efficacy against Solid Tumor
[Small] A CAR T cell membrane-camouflaged nanocatalyst (ACSP@TCM) was prepared to augment CAR T cell therapy efficacy against solid tumors. ACSP@TCM was prepared by encapsulating core/shell Au/Cu2-xSe and 3-bromopyruvate with a CAR T cell membrane.
Generation of Allogeneic CAR-NKT Cells from Hematopoietic Stem and Progenitor Cells Using a Clinically Guided Culture Method
[Nature Biotechnology] The authors described a clinically guided method to differentiate and expand IL-15-enhanced allogeneic CAR-NKT cells with high yield and purity.
Efficacy and Safety of Novel Multifunctional M10 CAR-T Cells in HIV-1-Infected Patients: A Phase I, Multicenter, Single-Arm, Open-Label Study
[Cell Discovery] Investigators reported newly developed anti-HIV-1 CAR-T cells armed with endogenic broadly neutralizing antibodies (bNAbs) and the follicle-homing receptor CXCR5, termed M10 cells.
Valrubicin-Loaded Immunoliposomes for Specific Vesicle-Mediated Cell Death in the Treatment of Hematological Cancers
[Cell Death & Disease] Following the transplantation of human pediatric B-cell acute lymphoblastic leukemia, T-cell acute lymphoblastic leukemia, or acute myeloid leukemia in immunodeficient NSG mice, investigators generated patient-derived xenograft models, which were treated with valrubicin-loaded immunoliposomes loaded with antibodies to target CD19, CD7 or CD33.
GLUT1 Overexpression Enhances CAR T Cell Metabolic Fitness and Anti-Tumor Efficacy
[Molecular Therapy] Using mouse models of acute lymphoblastic leukemia (ALL), renal cell carcinoma (RCC), and glioblastoma (GBM), we show that enforced expression of the glucose transporter GLUT1 enhances anti-tumor efficacy and promotes favorable CAR T cell phenotypes for two clinically relevant CAR designs, 19-28z and IL13Rα2-BBz.
BCKDK Modification Enhances the Anticancer Efficacy of CAR-T Cells by Reprogramming Branched Chain Amino Acid Metabolism
[Molecular Therapy] Investigators evaluated the efficacy of CAR T cell-mediated cancer cell lysis potential in the immune microenvironment of Branched Chain Amino Acids supplementation and deletion.
Targeting TGFβ-Activated Kinase-1 Activation in Microglia Reduces CAR T Immune Effector Cell-Associated Neurotoxicity Syndrome
[Nature Cancer] Researchers examined the role of microglia using mouse models and cohorts of individuals with ICANS. CD19-directed CAR (CAR19) T cell transfer in B cell lymphoma-bearing mice caused microglia activation and neurocognitive deficits.
Human Dental Pulp Stem Cells Mitigate the Neuropathology and Cognitive Decline via AKT-GSK3β-Nrf2 Pathways in Alzheimer’s Disease
[International Journal Of Oral Science] The authors demonstrated that human dental pulp stem cells mediated oxidative stress improvement and neuroreparative effects in in vitro Alzheimer’s disease models, playing critical roles in regulating the polarization of hyperreactive microglia cells and the recovery of damaged neurons.
RNA Aggregates Harness the Danger Response for Potent Cancer Immunotherapy
[Cell] Researchers created “onion-like” multi-lamellar RNA lipid particle aggregates to substantially enhance the payload packaging and immunogenicity of tumor mRNA antigens.
Stealth Transgenes Enable CAR-T Cells to Evade Host Immune Responses
[Journal For Immunotherapy Of Cancer] Scientists implemented a one-shot approach to prevent rejection of engineered T cells by simultaneously reducing antigen presentation and the surface expression of both Classes of the major histocompatibility complex (MHC) via expression of the viral inhibitors of transporter associated with antigen processing in combination with a transgene coding for shRNA targeting class II MHC transactivator.
Single-Cell Transcriptome Landscape and Cell Fate Decoding in Human Brain Organoids after Transplantation
[Advanced Science] To explore cell fate changes of human brain organoids before and after transplantation, human brain organoids are transplanted into prefrontal cortex and hippocampus, respectively.
Published since 2002, Cell Therapy News is our longest running online publication. Our editorial team curates the top publications, reviews, and news on in vivo gene therapy, cell therapy, and immunotherapy research. With over 15,000 subscribers and followers across our website, email newsletter, and Twitter feed, we are proud to facilitate the communication of cutting-edge cell therapy innovations.
