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Cancer Stem Cell News is an online resource that curates the top research publications and reviews about cancer progenitor cells and cancer stem cells.
Sumoylated Etv1 Establishes Mouse Mammary Cancer Stem Cells That Support Tumorigenesis by Non-Stem Cancer Cells
[Developmental Cell] Investigators found that inhibition of the small ubiquitin-like modifier pathway blocked Neu-mediated mammary oncogenesis and inhibited the function of CSCs/tumor-initiating cells without effects on normal mammary stem cells.
KLF7-Regulated ITGA2 As a Therapeutic Target for Inhibiting Oral Cancer Stem Cells
[Cell Death & Disease] Researchers confirmed the key role of KLF7 in maintaining the stemness of oral squamous cell carcinoma. Using chromatin immunoprecipitation sequencing and dual-luciferase assays, they identified ITGA2, a membrane receptor, as a key downstream gene regulated by KLF7 in the maintenance of stemness.
Clofoctol Impairs the Stemness of Gastric Cancer and Induces TNF-Mediated Necroptosis by Directly Binding to RanBP2
[Cellular and Molecular Life Sciences] Researchers discovered that clofoctol may exert potent therapeutic effects against gastric cancer by targeting β-catenin and inhibiting the viability of gastric cancer stem cells.
Role of KLF5 in Enhancing Ovarian Cancer Stemness and PARPi Resistance: Mechanisms and Therapeutic Targeting
[Journal of Translational Medicine] Scientists investigated the role of KLF5 in regulating ovarian cancer cell stemness and contributing to poly(ADP-ribose) polymerase inhibitors (PARPi) resistance.
NF-Kappa-B Inhibitor Alpha Mediates Cancer Stemness Characteristics in Oral Squamous Cell Carcinoma by Interacting with Cathepsin B
[International Journal of Biological Macromolecules] Investigators reported elevated levels of NKFBIA mRNA and NF-kappa-B inhibitor alpha protein in oral squamous cell carcinoma (OSCC) tumor tissues and OSCC cell lines.
Moleculin Announces World Health Organization Approval of “Naxtarubicin” As International Non-Proprietary Name for Annamycin
[Moleculin Biotech, Inc.] Moleculin Biotech, Inc. announced that the International Nonproprietary Names Expert Committee of the World Health Organization approved “naxtarubicin” for the non-proprietary name of the company’s next-generation anthracycline in development for the treatment of relapsed or refractory acute myeloid leukemia and soft tissue sarcoma lung metastases.
m6a/IGF2BP3-Driven Serine Biosynthesis Fuels AML Stemness and Metabolic Vulnerability
[Nature Communications] Researchers identified RNA N6-methyladenosine (m6A) modification as a key regulator of serine biosynthesis in acute myeloid leukemia.
Preclinical Targeting of Leukemia-Initiating Cells in the Development Future Biologics for Acute Myeloid Leukemia
[Expert Opinion On Therapeutic Targets] The authors summarize preclinical advances in targeting acute myeloid leukemia leukemia-initiating cells, including strategies to exploit metabolic vulnerabilities, such as the reliance on oxidative phosphorylation.
Different Features of Acute Myeloid Leukemia Stem Cell Quantification in Intensively Treated Patients
[Haematologica] Since different methods of leukemic stem cell quantification have been proposed, scientists determined the prognostic value on overall survival and incidence of relapse of these methods across ELN2017 risk groups, using data from the HOVON-SAKK132 trial.
SIRT4 Promotes Pancreatic Cancer Stemness by Enhancing Histone Lactylation and Epigenetic Reprogramming Stimulated by Calcium Signaling
[Advanced Science] Scientists revealed that the voltage-gated calcium channel subunit α2δ1-mediated calcium signaling can upregulate the expression of SIRT4, which is highly expressed in α2δ1-positive pancreatic tumor-initiating cells.
A Novel Model of Glioblastoma Recurrence to Identify Therapeutic Vulnerabilities
[EMBO Molecular Medicine] Researchers designed and characterized a novel induced-recurrence model in which mice xenografted with primary patient-derived glioma initiating/stem cells are treated with a therapeutic regimen closely recapitulating patient standard of care, followed by monitoring until tumours recur.
NR2F2 and Its Contribution to Lymph Node Metastasis in Oral Squamous Cell Carcinoma
Investigators explored the role of CSCs in lymph node metastasis of oral squamous cell carcinoma, focusing on the expression and biological significance of nuclear...
Cancer Stem Cell News consolidates the most recent publications covering research areas such as the identification and isolation of cancer stem cells, their proliferation and differentiation characteristics, gene expression and regulatory pathways, and the development of anti-cancer therapies. We also include cancer stem cell jobs and events hosted by leading research organizations, societies, and institutes.
