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Cancer Stem Cell News
Cancer Stem Cell News is an online resource that curates the top research publications and reviews about cancer progenitor cells and cancer stem cells.
Role of CD133 Antibody-Conjugated Nanocarrier in Enhancing the Targetability of Hepatocellular Carcinoma Stem Cells
[Scientific Reports] Scientists aimed at targeting hepatic cancer stem cells with quercetin or kaempferol loaded into poly(lactide-co-glycolide) nanoparticles decorated with CD133 antibody.
Activation of a Nongenetic AHR-ELMSAN1 Axis Optimizes BET-Targeting Therapy and Suppresses Leukemia Stem Cells in Preclinical Models
[Science Translational Medicine] Scientists uncovered a MYC-repressive, nongenetic AHR-ELMSAN1 axis that enhances BET-targeting therapies and selectively impairs leukemia stem cells, providing a compelling rationale for clinical translation in AML and potentially other MYC-driven cancers.
Targeting MCM10 Disrupts Cancer Stemness and Counteracts Sorafenib Resistance in Hepatocellular Carcinoma
[Cancer Gene Therapy] Investigators found that minichromosome maintenance complex component 10 (MCM10) plays a pivotal role in promoting cancer stemness and sorafenib resistance in hepatocellular carcinoma.
NSUN2-Mediated M5c Modification of PGK1 mRNA Promotes Cell Growth, Invasion, Stemness, and Glycolysis in Gastric Cancer
[Cell Cycle] Researchers found that phosphoglycerate kinase 1 (PGK1) overexpression reversed the inhibitory effect of NSUN2 knockdown on gastric cancer cell growth, invasion, stemness, and glycolysis.
Vibrational Spectroscopy Unveils Distinct Cell Cycle Features of Cancer Stem Cells in Melanoma
[Scientific Reports] Scientists explored the biochemical and regulatory dynamics of CSCs identified by using a time-course design, integrating infrared and Raman spectroscopies with cell cycle analysis and immunocytochemistry targeting the checkpoint proteins p16 and p21.
A FUT2-β-catenin Axis Mediates Chemoresistance and Cancer Stemness in Lung Adenocarcinoma
[Cellular Signalling] Functional experiments showed that fucosyltransferase 2 (FUT2) knockdown in lung adenocarcinoma (LUAD) increased chemotherapy sensitivity by enhancing ferroptosis susceptibility. FUT2 knockdown suppressed cancer stemness in LUAD.
Investigation of MANF Regulation of Glioma Stemness via STAT3/TGF-β/SMAD4/P38 Pathway Based on Pan-Cancer Analysis
[Translational Oncology] Endogenous mesencephalic astrocyte-derived neurotrophic factor (MANF) regulates tumor cells by modulating the TGF-β/SMAD4/p38 pathway, promoting stemness and enhancing malignant behaviors, including migration and invasion.
Machine Learning on Multiple Epigenetic Features Reveals H3K27Ac As a Driver of Gene Expression Prediction across Patients with Glioblastoma
[PLoS Computational Biology] Scientists suggested that glioblastoma stem cells (GSCs) share a common distributional pattern of enhancer activity characterized by H3K27Ac, which can be utilized to predict gene expression in GSCs across patients.
Role of the TGF-β/Smad3 Pathway in Pancreatic Cancer Cell Growth and Stem Cell Characteristics
[Discover Oncology] Researchers investigated the involvement of the transforming growth factor-β/small mothers against decapentaplegic 3 (TGF-β/Smad3) pathway in pancreatic cancer (PC) development and stem cell-like properties by examining its regulatory effects on PC cells.
An Endolichenic Fungi-Derived Fatty Acid, Cis-10-Nonadecenoic Acid, Suppresses Colorectal Cancer Stemness
[Biomolecules & Therapeutics] cis-10-nonadecenoic acid, isolated through bioactivity-guided fractionation, exerted substantial inhibitory effects on CRC stemness, such as the suppression of spheroid formation and the downregulation of the key stem cell markers ALDH1, CD44, and CD133.
Cancer Stem Cells: Landscape, Challenges, and Emerging Therapeutic Innovations
[Signal Transduction and Targeted Therapy] The authors discuss the latest advancements in CSC biology, highlight key challenges, and explore future perspectives on translating these findings into clinical applications.
Stem Cell Therapies and Glioma Stem Cells in Glioblastoma: A Systematic Review of Current Challenges and Research Directions
[International Journal of Emergency Medicine] Investigators assess and consider the potential therapeutic benefits, challenges, and prospective research directions for tem cell therapies for glioblastoma with a particular focus on glioma stem cells as key therapeutic targets.
Cancer Stem Cell News consolidates the most recent publications covering research areas such as the identification and isolation of cancer stem cells, their proliferation and differentiation characteristics, gene expression and regulatory pathways, and the development of anti-cancer therapies. We also include cancer stem cell jobs and events hosted by leading research organizations, societies, and institutes.
