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Cancer Stem Cell News is an online resource that curates the top research publications and reviews about cancer progenitor cells and cancer stem cells.
Multimodal Decoding of Human Liver Regeneration
[Nature] The authors uncovered a novel ANXA2+ migratory hepatocyte subpopulation, which emerged during human liver regeneration, and a corollary subpopulation in a mouse model of acetaminophen-induced liver regeneration.
TLR3 Activation Enhances Abscopal Effect of Radiotherapy in HCC by Promoting Tumor Ferroptosis
[EMBO Molecular Medicine] Scientists demonstrated that subcutaneous administration of Toll-like receptor 3 (TLR3) agonist poly(I:C) could strengthen the abscopal effect during radiotherapy through activating tumor cell ferroptosis signals in bilateral HCC subcutaneous tumor mouse models, which could be significantly abolished by TLR3 knock-out or ferroptosis inhibitor ferrostatin-1.
Genetic and Phenotypic Profiling of Single Living Circulating Tumor Cells from Patients with Microfluidics
[Proceedings Of The National Academy Of Sciences Of The United States Of America] Researchers described the nanoplatform for interrogating living cell host-gene and (micro-)environment relationships, that integrates micro- and nanofluidics to enable highly efficient capture of circulating tumor cells from blood samples.
Circadian Regulation of Cancer Stem Cells and the Tumor Microenvironment During Metastasis
[Nature Cancer] The authors review how the circadian clock influences CSCs and their local tumor niches in the context of different stages of tumor metastasis.
Identification of a Set of Genes Potentially Responsible for Resistance to Ferroptosis in Lung Adenocarcinoma Cancer Stem Cells
[Cell Death & Disease] The authors observed that the ferroptosis inducer RSL3 triggered lipid peroxidation and cell death in lung adenocarcinoma cells when grown in 2D conditions; however, when grown in 3D conditions, all cell lines underwent a phenotypic switch, exhibiting substantial resistance to RSL3 and, therefore, protection against ferroptotic cell death.
The CD33xCD123xCD70 Multispecific CD3-Engaging DARPin MP0533 Induces Selective T Cell–Mediated Killing of AML Leukemic Stem Cells
[Cancer Immunology Research] Researchers designed MP0533, a multispecific CD3-engaging designed ankyrin repeat protein that could simultaneously bind to three antigens on AML cells, CD33, CD123, and CD70, aiming to enable avidity-driven T cell–mediated killing of AML cells co-expressing at least two of the antigens.
NAT10-Mediated ac4C Modification Promotes Stemness and Chemoresistance of Colon Cancer by Stabilizing NANOGP8
[Heliyon] The levels of NAT10 in normal colon and chemoresistant colon cancer tissues were determined utilizing quantitative real-time polymerase chain reaction alongside immunohistochemistry.
VC-Resist Glioblastoma Cell State: Vessel Co-Option as a Key Driver of Chemoradiation Resistance
[Nature Communications] Using a combination of transcriptomic, proteomic, and phosphoproteomic analyses, longitudinal imaging, organotypic cultures, functional assays, animal studies, and clinical data analyses, we demonstrate that chemoradiation and brain vasculature induce cell transition to a functional state named VC-Resist.
The pRb/RBL2-E2F1/4-GCN5 Axis Regulates Cancer Stem Cell Formation and G0 Phase Entry/Exit by Paracrine Mechanisms
[Nature Communications] Investigators used a quantitative proteomic approach for identifying secreted proteins of CSCs in pancreatic cancer. They uncovered that the cell-autonomous E2F1/4-pRb/RBL2 axis balanced non-cell-autonomous signaling in healthy ductal cells but became deregulated upon KRAS mutation.
Macrophage-Fibroblast JAK/STAT Dependent Crosstalk Promotes Liver Metastatic Outgrowth in Pancreatic Cancer
[Nature Communications] Scientists identified three functionally distinct metastasis-associated fibroblast populations, among which the generation of pro-metastatic and immunoregulatory myofibroblastic-MAFs critically depended on macrophages.
Autonomous Circadian Rhythms in the Human Hepatocyte Regulate Hepatic Drug Metabolism and Inflammatory Responses
[MIT News] Investigators established and characterized an in vitro liver experimental system in which primary human hepatocytes display self-sustained oscillations.
METTL14 Downregulation Drives S100A4+ Monocyte-Derived Macrophages via MyD88/NF-κB Pathway to Promote MAFLD Progression
[Signal Transduction And Targeted Therapy] In vivo and in vitro mechanistic studies indicated that METTL14 downregulation decreased the level of GLS2 by affecting the translation efficiency mediated by YTHDF1 in an m6A-depedent manner, which might help to form an oxidative stress microenvironment and accordingly recruit Cx3cr1+Ccr2+ monocyte-derived macrophages.
Cancer Stem Cell News consolidates the most recent publications covering research areas such as the identification and isolation of cancer stem cells, their proliferation and differentiation characteristics, gene expression and regulatory pathways, and the development of anti-cancer therapies. We also include cancer stem cell jobs and events hosted by leading research organizations, societies, and institutes.
