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Cancer Stem Cell News
Cancer Stem Cell News is an online resource that curates the top research publications and reviews about cancer progenitor cells and cancer stem cells.
Nanomaterials for Delivery of Drugs and Genes to Disrupt Notch Signaling Pathway in Breast Cancer
[Naunyn-Schmiedebergs Archives of Pharmacology] The authors examine recent breakthroughs in nanocarrier systems aimed at the Notch signaling pathway in breast cancer, highlighting the therapeutic potential of integrating nanomedicine with Notch inhibition to disrupt epithelial-mesenchymal transition, tumor-initiating cells, and metastasis, thereby enhancing clinical outcomes.
Cytoplasmic Connexin43-Microtubule Interactions Promote Glioblastoma Stem-Like Cell Maintenance and Tumorigenicity
[Cell Death & Disease] Using a connexin43 (Cx43) mimetic peptide of the carboxyl-terminal tubulin-binding domain of Cx43 (JM2), investigators successfully disrupted Cx43 interaction with microtubules in gastric stem cells.
Kinesin Family Member 4 a Drives Cancer Stem Cell Characteristics in Breast Cancer: Insights from scRNA-Seq and Experimental Validation
[International Journal of Biological Macromolecules] Investigators identified cancer stem cell marker genes in breast cancer through an integrated analysis of single cell RNA sequencing and bulk RNA sequencing data.
USP18 Deubiquitinates and Stabilizes SOX9 to Promote the Stemness and Malignant Progression of Glioblastoma
[Cell Death Discovery] Scientists focused on ubiquitin-specific peptidase 18 (USP18), a member of the deubiquitinase family whose role in glioblastoma is poorly understood.
Nuclear circGUSBP1 Promotes Cancer Stemness via Transcriptional Coordination with OCT4
[Life Sciences] Researchers investigated nuclear circRNAs and their roles in regulating cancer stem-like properties in ndometrial cancer .
The Cancer Stem Cells Characteristics Analysis of LGR5 + Cells That Influence Lung Cancer Risk by Using Single Cell RNA-Seq Analysis
[Scientific Reports] Investigators performed a single-cell RNA-seq analysis to explore the characteristics of cancer stem cells in lung adenocarcinoma.
Delta 4-Desaturase Sphingolipid 2 Enhances Prostate Cancer Stem-Like Traits through Phytoceramide-Mediated PI3K-AKT Signaling Pathway
[Carcinogenesis] Scientists conducted gene expression profiling of sphere-derived castration-resistant prostate cancer stem cells (PCSCs) and identified enhanced sphingolipid de novo biosynthesis with upregulated DEGS2 expression in PCSCs.
GLUT1 Maintains Esophageal Cancer Stem Cell-Like Characteristics by Inhibiting Autophagy-Dependent Ferroptosis via EGFR
[Experimental Cell Research] Investigators investigated the molecular mechanism by which glucose transporter 1 (GLUT1) maintains esophageal CSC-like properties through regulation of autophagy-dependent ferroptosis via epidermal growth factor receptor (EGFR).
Effects of Integrin-Linked Kinase Silencing Combined with Trichostatin a on Cancer Stem Cells
[Oral Diseases] Scientists investigated the effects of integrin-linked kinase silencing and trichostatin A treatment on CSCs, assessing their potential to diminish CSC properties and inhibit oral squamous cell carcinoma progression.
Quantifying Mechanical, Proliferation, and Migrational Properties of Bulk Ovarian Cancer Cells, and Ovarian Cancer Stem Cells
[Acta Histochemica] Researchers analyzed the mechanical and migrational properties of ovarian cancer stem cells with the well-researched bulk ovarian cancer cells.
Patient-Derived Organoid Co-Culture Systems As Next-Generation Models for Bladder Cancer Stem Cell Research
[Cancer Letters] The authors provide a comprehensive overview of the recent advancements in patient-derived organoids co-culture systems designed to integrate tumor microenvironment elements.
Adenine Nucleotide Translocase 2 Silencing Promotes Metabolic Reprogramming in P19 Embryonal Carcinoma Stem Cells
[Biochimica Et Biophysica Acta-Molecular Basis of Disease] Scientists underscore adenine nucleotide translocator 2 (ANT2) as a key regulator of metabolic remodeling and cell survival of cancer stem-like cells, suggesting its potential as a therapeutic target for controlling CSC-driven tumor progression.
Cancer Stem Cell News consolidates the most recent publications covering research areas such as the identification and isolation of cancer stem cells, their proliferation and differentiation characteristics, gene expression and regulatory pathways, and the development of anti-cancer therapies. We also include cancer stem cell jobs and events hosted by leading research organizations, societies, and institutes.
