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Cancer Stem Cell News
Cancer Stem Cell News is an online resource that curates the top research publications and reviews about cancer progenitor cells and cancer stem cells.
Tofacitinib and Budesonide Treatment Affect Stemness and Chemokine Release in IBD Patient-Derived Colonoids
[Scientific Reports] Researchers investigated cellular effects of pan-Janus Kinase inhibitor tofacitinib and the corticosteroid budesonide on uninflamed and TNF + Poly(I:C) stimulated human colon organoids from healthy donors and inflammatory bowel disease-patients.
CD36 Enrichment in HER2-Positive Mesenchymal Stem Cells Drives Therapy Refractoriness in Breast Cancer
[Journal of Experimental & Clinical Cancer Research] Scientists elucidated whether enhanced CD36 in mesenchymal HER2 + CSCs was directly involved in anti-HER2 treatment refractoriness in HER2 + breast cancer and to design future metabolism-based approaches targeting both fatty acid reprogramming and the “root” of cancer.
Crosstalk Between GLTSCR1-Deficient Endothelial Cells and Tumour Cells Promotes Colorectal Cancer Development by Activating the Notch Pathway
[Cell Death & Differentiation] Researchers revealed that endothelial cell-specific GLTSCR1 deletion promotes colorectal cancer tumorigenesis and metastasis by increasing cancer cell stemness.
A Novel USP4 Inhibitor That Suppresses Colorectal Cancer Stemness by Promoting β-Catenin and Twist1 Degradation
[Journal of Translational Medicine] Investigators identified key deubiquitinating enzymes regulating CSCs and drug resistance of colorectal cancer (CRC). Gain- and loss-of-function experiments were performed to evaluate the function of USP4 in the regulation of stemness and drug sensitivity in CRC.
CXCR4 Promotes Tumor Stemness Maintenance and CDK4/6 Inhibitors Resistance in ER-Positive Breast Cancer
[Breast Cancer Research] Investigators focused on cancer stem cells, a critical contributor to cancer metastasis and therapy resistance, and detected an upregulation of stemness in our established palbociclib-resistant ER-positive breast cancer cells.
A Novel Therapeutic Strategy Utilizing EpCAM Aptamer-Conjugated Gemcitabine for Targeting Bladder Cancer and Cancer Stem Cells
[Biomaterials Science] To enhance the anti-cancer effect and reduce the side effects of gemcitabine (GEM) targeting bladder cancer (BCa) cells/CSCs, an aptamer drug conjugate targeted delivery system was used to improve the efficiency of GEM in BCa therapy using epithelial cell adhesion molecule (EpCAM) aptamer-GEM conjugates based on the EpCAM, which was highly expressed on the cell membrane of BCa cells/CSCs.
CD271high Cancer Stem Cells Regulate Macrophage Polarization in Head and Neck Squamous Cell Carcinoma
[Oral Oncology] Scientists investigated the stemness characteristics of CD271high head and neck squamous cell carcinoma and their interactions with the tumor immune microenvironment.
Dandelion Extract Suppresses the Stem-Like Properties of Triple-Negative Breast Cancer Cells by Regulating CUEDC2/β-Catenin/OCT4 Signaling Axis
[Journal of Ethnopharmacology] Researchers examined the impact of dandelion extract on the stemness properties of triple-negative breast cancer (TNBC) and delineated the underlying mechanisms. Pharmacological network analysis revealed the potential regulatory effects of dandelion extract on TNBC stemness.
KHSRP Promotes Cancer Stem Cell Maintenance, Tumorigenesis, and Suppresses Anti-Tumor Immunity in Gastric Cancer
[Oncology Research] Gain- and loss-of-function experiments were conducted to assess KH-type splicing regulatory protein (KHSRP’s) effects on gastric cancer cell proliferation, stemness, and migration.
Chlorpyrifos Induces Lung Metastases and Modulation of Cancer Stem Cell Markers in Triple Negative Breast Cancer Model.
[Toxicology] Researchers studied the expression of breast cancer stem cells and epithelial-mesenchymal transition activation-markers in triple-negative breast cancer mice tumors and human cells.
Beyond Chemotherapy: Exploring 5-FU Resistance and Stemness in Colorectal Cancer
[European Journal of Pharmacology] Investigators explore the complexities of targeting colorectal cancer stem cells and the mechanisms contributing to resistance to 5-fluorouracil (5-FU).
Insights on BMI-1 Therapeutic Targeting in Head and Neck Cancers
[Oncology Research] Current biological insights of B lymphoma Mo-MLV insertion region 1 homolog (Bmi-1_ as a master regulator of stem cell self-renewal have emerged as a prominent player in cancer stem cell biology. The authors synthesize the current knowledge on Bmi-1 with an emphasis on the role that Bmi-1 plays in oral cancer progression and evaluates how this can be used in advancing clinical treatment strategies for head and neck cancer.
Cancer Stem Cell News consolidates the most recent publications covering research areas such as the identification and isolation of cancer stem cells, their proliferation and differentiation characteristics, gene expression and regulatory pathways, and the development of anti-cancer therapies. We also include cancer stem cell jobs and events hosted by leading research organizations, societies, and institutes.
