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Cancer Stem Cell News
Cancer Stem Cell News is an online resource that curates the top research publications and reviews about cancer progenitor cells and cancer stem cells.
N6-Methyladenosine-Modified Long Non-Coding RNA KIF9-AS1 Promotes Stemness and Sorafenib Resistance in Hepatocellular Carcinoma by Upregulating SHOX2 Expression
[World Journal of Gastroenterology] Investigators described the role of the lncRNA KIF9-AS1 in cancer stemness and drug resistance in hepatocellular carcinoma and elucidated the underlying mechanism.
Nicotine Enhances the Stemness and Tumorigenicity in Intestinal Stem Cells via Hippo-YAP/TAZ and Notch Signal Pathway
[eLife] Researchers identified a nicotine-triggered pathway regulating the stemness and tumorigenicity of intestinal stem cells and suggested the use of dibenzazepine as a potential therapeutic strategy for treating intestinal tumors.
Downregulation of PAX1 in OSCC Enhances Stemness and Immunosuppression via IFIT1 and PD-L1 Pathways
[Oral Diseases] Researchers investigated how arecoline-induced extracellular vesicle secretion suppresses PAX1 protein production through DNA hypermethylation and examined whether PAX1 downregulation enhances cancer stemness and immunosuppression in the tumor microenvironment.
GPLD1+ Cancer Stem Cells Contribute to Chemotherapy Resistance and Tumor Relapse in Intestinal Cancer
[Journal of Biochemistry] Scientists suggested that targeting of glycosylphosphatidylinositol-specific phospholipase D1 (GPLD1) in colorectal cancer might contribute to a new therapeutic strategy that was based on suppression of Wnt signaling and epithelial-mesenchymal transition-related cancer progression driven by cancer stem cells.
The IL-10/STAT3 Axis Nasopharyngeal Carcinoma Cancer Stem Cell and Radio Resistance
[Scientific Reports] Investigators found that IL-10 was up-regulated in CSC. IL-10 enhanced the self-renewal and tumorigenesis of nasopharyngeal CSC.
A Magnetic-Responsive Biomimetic Nanosystem Coated with Glioma Stem Cell Membranes Effectively Targets and Eliminates Malignant Gliomas
[Biomaterials Research] This study positioned FDPM, a magnetic-responsive biomimetic nanosystem, as a promising nanoplatform to target glioma stem cells and related tumor cells for improving the therapeutic effect of glioma.
Calpain 2 Promotes Lenvatinib Resistance and Cancer Stem Cell Traits via Both Proteolysis-Dependent and Independent Approach in Hepatocellular Carcinoma
[Molecular Biomedicine] Researchers employed integrated bioinformatic analysis to identify calpain-2 as a novel key regulator for Lenvatinib resistance in HCC, and its expression greatly increased in both Lenvatinib-resistant HCC cell lines and clinical samples.
MACC1 Ablation Suppresses the Dedifferentiation Process of Non-CSCs in Lung Cancer Through Stabilizing KLF4
[Cell Death Discovery] The authors showed that metastasis-associated in colon cancer-1 (MACC1) promoted the transition from non-cancer stem cell (CSC) to CSC in lung cancer.
CALML3-AS1 Enhances Malignancies and Stemness of Small Cell Lung Cancer Cells through Interacting with DAXX Protein and Promoting GLUT4-Mediated Aerobic Glycolysis
CALML3 antisense RNA 1 (CALML3-AS1), an oncogene, promoted the malignancy and stemness of small cell lung cancer (SCLC) cells by interacting with death domain-associated...
Stabilization of SQLE mRNA by WTAP/FTO/IGF2BP3-Dependent Manner in HGSOC: Implications for Metabolism, Stemness, and Progression
[Cell Death & Disease] Squalene epoxidase overexpression resulted in enhanced cancer stem cell-like properties, including increased tumorsphere formation and stemness markers expression.
Aging Limits Stemness and Tumorigenesis by Reprogramming Iron Homeostasis
[Nature] Investigators used physiologically aged autochthonous genetically engineered mouse models and primary cells to demonstrate that ageing suppresses lung cancer initiation and progression by degrading the stemness of the alveolar cell of origin.
Cannabidiol Effects in Stem Cells: A Systematic Review
[Biofactors] In this systematic review, the authors analyzed the effect of cannabidiol on both somatic stem cells and cancer stem cells.
Cancer Stem Cell News consolidates the most recent publications covering research areas such as the identification and isolation of cancer stem cells, their proliferation and differentiation characteristics, gene expression and regulatory pathways, and the development of anti-cancer therapies. We also include cancer stem cell jobs and events hosted by leading research organizations, societies, and institutes.
