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Cancer Stem Cell News is an online resource that curates the top research publications and reviews about cancer progenitor cells and cancer stem cells.
Isolation and Identification of Patient-Derived Liver Cancer Stem Cells and Development of Personalized Treatment Strategies
[Journal of Translational Medicine] Scientists introduced an effective approach to isolate and culture liver cancer stem cells from human primary liver cancer, leveraging mouse embryonic fibroblasts as feeder cells in conjunction with using defined medium.
Rhaponticin Suppresses the Stemness Phenotype of Gastric Cancer Stem-Like Cells CD133+/CD166 + by Inhibiting Programmed Death-Ligand 1
[BMC Gastroenterology] Gastric cancer stem cells were isolated using CD133 and CD166 markers with magnetic bead separation method. Then they evaluated their response to the IC50 concentrations of rhaponticin, and effects on cell proliferation, migration, invasion, and stemness were measured.
USP10 Deubiquitinates and Stabilizes CD44 Leading to Enhanced Breast Cancer Cell Proliferation, Stemness and Metastasis
[Biochemical Journal] While USP10 depletion prominently downregulated CD44 protein levels and functions, its overexpression significantly enhanced CD44 protein levels, leading to enhanced cluster tumor cell formation, stemness, and metastasis in breast cancer cells both in vitro and ex vivo in primary human breast tumor cells.
METTL14 Suppresses the Expression of YAP1 and the Stemness of Triple-Negative Breast Cancer
[Journal of Experimental & Clinical Cancer Research] Researchers presented an epi-transcriptional mechanism that maintained Hippo-independent YAP1 signaling and played a role in preserving the undifferentiated state of triple-negative breast cancer (TNBC), which indicated the potential for targeting the LSD1-METTL14 axis to address TNBC stemness.
GNAO1 Overexpression Promotes Neural Differentiation of Glioma Stem-Like Cells and Reduces Tumorigenicity Through TRIM21/CREB/HES1 Axis
[Oncogene] Investigators identified G Protein Subunit Alpha O1 (GNAO1) as a critical regulator of neural differentiation of glioma stem-like cells. GNAO1 expression was lower in gliomas than in normal neuronal tissues and high expression of GNAO1 correlated with a better prognosis.
P4HB Maintains Wnt-Dependent Stemness in Glioblastoma Stem Cells as a Precision Therapeutic Target and Serum Marker
[Oncogenesis] Using bioinformatics and experimental analysis, scientists identified P4HB, a protein disulfide isomerase, as a serum marker that maintains stemness in glioblastoma stem cells through the Wnt/β-catenin signaling pathway.
Myofibroblast-Derived Extracellular Vesicles Facilitate Cancer Stemness of Hepatocellular Carcinoma via Transferring ITGA5 to Tumor Cells
[Molecular Cancer] Researchers elucidated a novel mechanism by which the extracellular vesicle-mediated transfer of integrin α5 (ITGA5) from myofibroblasts to tumor cells augmented hepatocellular carcinoma (HCC) stemness. ITGA5-targeting therapy helped prevent the progression of HCC and improved the efficacy of PD-L1 treatment.
PTBP1 Lactylation Promotes Glioma Stem Cell Maintenance through PFKFB4-Driven Glycolysis
[Cancer Research] Investigators demonstrated that global lactylation was significantly elevated in glioma stem cells (GSCs) compared to differentiated glioma cells. PTBP1, a central regulator of RNA processing, was hyperlactylated in GSCs, and SIRT1 induced PTBP1 delactylation.
Synthesis, Characterization, and Anti-Tumor Activity of Nano-Immuno-Conjugates for Enhanced Photodynamic Therapy of Oesophageal Cancer Stem Cells
[Biomedicine & Pharmacotherapy] Scientists employed a strategy to target oesophageal oesophageal cancer stem cells with a nano-immuno-conjugate consisting of AlPcS4Cl, gold nanoparticle and anti-CD271 antibody synthesised using a chemical reaction.
Telomerase Inhibition in Breast Cancer and Breast Cancer Stem Cells: A Brief Review
[Medical Oncology] The authors examine telomerase activation in breast cancer and breast cancer stem cells and the therapeutic effects of telomerase inhibition in these cells.They highlight the importance and impact of telomerase inhibition in the treatment of breast cancer and the lack of studies specifically in breast cancer stem cells.
Eisbach Bio Secures CPRIT Grant to Advance Novel Cancer Therapeutic
[Eisbach Bio Gmbh] Eisbach Bio GmbH announced the receipt of a Texas Therapeutics Company Award from the Cancer Prevention and Research Institute of Texas (CPRIT). This prestigious grant of US $4.75 million will support the clinical development of Eisbach's first-in-class allosteric small molecule inhibitor EIS-12656 targeting ALC1.
Tumor Evolution and Microenvironment Interactions in 2D and 3D Space
[Nature] To study the spatial interactions among cancer and non-cancer cells, researchers examined a cohort of 131 tumor sections from 78 cases across 6 cancer types by Visium spatial transcriptomics.
Cancer Stem Cell News consolidates the most recent publications covering research areas such as the identification and isolation of cancer stem cells, their proliferation and differentiation characteristics, gene expression and regulatory pathways, and the development of anti-cancer therapies. We also include cancer stem cell jobs and events hosted by leading research organizations, societies, and institutes.
