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Cancer Stem Cell News is an online resource that curates the top research publications and reviews about cancer progenitor cells and cancer stem cells.
MACC1 Ablation Suppresses the Dedifferentiation Process of Non-CSCs in Lung Cancer Through Stabilizing KLF4
[Cell Death Discovery] The authors showed that metastasis-associated in colon cancer-1 (MACC1) promoted the transition from non-cancer stem cell (CSC) to CSC in lung cancer.
CALML3-AS1 Enhances Malignancies and Stemness of Small Cell Lung Cancer Cells through Interacting with DAXX Protein and Promoting GLUT4-Mediated Aerobic Glycolysis
CALML3 antisense RNA 1 (CALML3-AS1), an oncogene, promoted the malignancy and stemness of small cell lung cancer (SCLC) cells by interacting with death domain-associated...
Stabilization of SQLE mRNA by WTAP/FTO/IGF2BP3-Dependent Manner in HGSOC: Implications for Metabolism, Stemness, and Progression
[Cell Death & Disease] Squalene epoxidase overexpression resulted in enhanced cancer stem cell-like properties, including increased tumorsphere formation and stemness markers expression.
Aging Limits Stemness and Tumorigenesis by Reprogramming Iron Homeostasis
[Nature] Investigators used physiologically aged autochthonous genetically engineered mouse models and primary cells to demonstrate that ageing suppresses lung cancer initiation and progression by degrading the stemness of the alveolar cell of origin.
Cannabidiol Effects in Stem Cells: A Systematic Review
[Biofactors] In this systematic review, the authors analyzed the effect of cannabidiol on both somatic stem cells and cancer stem cells.
SUO-CTC and CG Oncology Announce the First Annual Non-Muscle Invasive Bladder Cancer (NMIBC) Research Fellowship Award
[CG Oncology, Inc.] The Society of Urologic Oncology Clinical Trials Consortium (SUO-CTC), and CG Oncology, Inc. announced the first annual CG-SUO-CTC NMIBC Research Fellowship designed to support the development of outstanding clinical cancer research investigators who have demonstrated a commitment to improving the understanding and treatment of NMIBC.
Dysregulation of the p53 Pathway Provides a Therapeutic Target in Aggressive Pediatric Sarcomas with Stem-Like Traits
[Cellular Oncology] Investigators showed that restoring canonical p53 activity provided a promising strategy for developing improved therapies for pediatric sarcomas with unfavorable stem-like traits.
YAP1 Induces Bladder Cancer Progression and Promotes Immune Evasion Through IL-6/ STAT3 Pathway and CXCL Deregulation
[Journal of Clinical Investigation] Investigators provided insights on YAP1 signaling as a driver for cancer stemness and an inducer of immunosuppressive tumor immune microenvironment.
Exosomal ETV4 Derived From M2 Macrophages Induces Growth, Glycolysis and Stemness in Hepatocellular Carcinoma by UpRegulating SULT2B1 Expression
[Liver International] ETV4 derived from M2 macrophage exosomes promoted hepatocellular carcinoma (HCC) cell proliferation, glycolysis and stemness in vitro, and enhanced HCC growth in nude mice.
CX43-Mediated Mitochondrial Transfer Maintains Stemness of KG-1a Leukemia Stem Cells Through Metabolic Remodeling
[Stem Cell Research & Therapy] Researchers increased mitochondria transferred from bone marrow mesenchymal stem/stromal cells supported metabolic remodeling in leukemia stem cells to sustained their stemness.
CCDC34 Maintains Stemness Phenotype Through β-Catenin-Mediated Autophagy and Promotes EGFR-TKI Resistance in Lung Adenocarcinoma
[Cancer Gene Therapy] Scientists found that CCDC34 may be associated with lung adenocarcinoma stemness through weighted gene co-expression network analysis.
Isolation and Identification of Patient-Derived Liver Cancer Stem Cells and Development of Personalized Treatment Strategies
[Journal of Translational Medicine] Scientists introduced an effective approach to isolate and culture liver cancer stem cells from human primary liver cancer, leveraging mouse embryonic fibroblasts as feeder cells in conjunction with using defined medium.
Cancer Stem Cell News consolidates the most recent publications covering research areas such as the identification and isolation of cancer stem cells, their proliferation and differentiation characteristics, gene expression and regulatory pathways, and the development of anti-cancer therapies. We also include cancer stem cell jobs and events hosted by leading research organizations, societies, and institutes.
