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Cancer Stem Cell News is an online resource that curates the top research publications and reviews about cancer progenitor cells and cancer stem cells.
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Cancer Stem Cells Orchestrate Immune Evasion through Extracellular Vesicle-Mediated Non-Canonical Signaling Pathways
[Cancer Cell] Using multiplexed single-cell proteomics to analyze 50 tumor microenvironment-associated proteins across treatment-naive triple-negative breast cancer specimens, we discovered that CSCs drive differentiation and expansion of regulatory T cells via extracellular vesicle-mediated paracrine signaling.
Leukemic Stem Cell Subtypes Determine Venetoclax Resistance and Therapeutic Vulnerabilities in AML
[Cell Stem Cell] Researchers revealed four distinct leukemic stem cell types with unique vulnerabilities and propose biomarker-guided treatment strategies that complement genetic profiling to overcome venetoclax resistance.
A Ketogenesis-Ferroptosis Axis Maintains Leukemic Stem Cell Survival and Leukemia Progression
[Cell Stem Cell] Scientists showed that leukemic stem cells in acute myeloid leukemia exhibit elevated ketogenesis, driven by fatty acid oxidation, to produce β-hydroxybutyrate.
MYOD1 Mutation Drives Cancer Stem Cell Pathways and Therapy-Resistance in Spindle Cell/Sclerosing Rhabdomyosarcoma
[Nature Communications] Investigators showed that recurrent L122R mutation in the DNA-binding site of the Myogenic Differentiation 1 (MYOD1) transcription factor increases cancer stem cell frequency in aggressive Spindle cell/sclerosing rhabdomyosarcoma.
IQGAP3 Bridges Matrix Stiffness with Glioma Stem Cell Maintenance and Radioresistance by Stabilizing SOX2
[Nature Communications] Researchers found that increased matrix stiffness promotes radioresistance in glioblastoma and maintains tumor cell hierarchies.
The WYZ-1 Mouse Glioblastoma Stem Cell Model: A Novel Preclinical Tool for Tumor and Therapy Studies
[Cancer Letters] Scientists established a novel syngeneic glioblastoma stem cell line from PDGFB-driven RCAS/tv-a glioblastomas and subsequently generated a Pten-deficient derivative, WYZ-1.
Low Expression of ONECUT2 Governs the POU6F2-Beta-Catenin Axis to Modulate Cancer Stemness and Drives the CCL28-Dependent Pathway for Macrophage Polarization in Breast Cancer
[Cell Death & Disease] Investigators demonstrated that inhibition of ONECUT2, a core transcription factor, potently drives CSC characteristics and reprograms the TIME to favor macrophage polarization to the M2-type, a tumor-promoting state.
Thr3/Ser90 Phosphorylation-Stabilized S100A8 Regulates Cholesterol Metabolism in Glioblastoma Stem Cells
[Oncogene] Scientists demonstrated that S100A8 was highly expressed in glioblastoma (GBM) stem cells and closely associated with shorter overall survival in GBM patients.
The Metabolic Plasticity of Cancer Stem Cells: Bidirectional Crosstalk with Organ-Resident Cells
[Experimental & Molecular Medicine] Investigators discuss the emerging potential of targeting CSC-supportive metabolic niches through drug repurposing, highlighting context-aware metabolic interventions as a pragmatic strategy to overcome CSC-driven treatment resistance.
Targeting Colorectal Cancer Stem-Like Cells: Overcoming Therapeutic Resistance and Reprogramming the Immunosuppressive Niche
[Cancer Letters] The authors provide a comprehensive analysis of the evolving landscape of immunotherapies designed to target colorectal cancer stem-like cells.
Lyell Immunopharma Provides Update on Safety Profile of LYL273 in Relapsed or Refractory Metastatic Colorectal Cancer and Amends Phase I Trial to Phase I/II...
[Lyell Immunopharma, Inc.] Lyell Immunopharma, Inc. provided an update on the safety profile of LYL273 in its ongoing US Phase I clinical trial in patients with relapsed or refractory metastatic colorectal cancer, and announced the Phase I trial has been amended to enable seamless expansion into a potential pivotal single-arm Phase II trial pending regulatory alignment.
IQGAP3 Bridges Matrix Stiffness with Glioma Stem Cell Maintenance and Radioresistance by Stabilizing SOX2
[Nature Communications] Differential gene expression revealed that stiff matrices induce expression of IQ Motif Containing GTPase Activating Protein 3 (IQGAP3) through YAP1 and TEAD transcription factors in GBM stem cells.
Cancer Stem Cell News consolidates the most recent publications covering research areas such as the identification and isolation of cancer stem cells, their proliferation and differentiation characteristics, gene expression and regulatory pathways, and the development of anti-cancer therapies. We also include cancer stem cell jobs and events hosted by leading research organizations, societies, and institutes.
