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Cancer Stem Cell News is an online resource that curates the top research publications and reviews about cancer progenitor cells and cancer stem cells.
OTUB1 Mediates PARP1 Deubiquitination to Alleviate NAFLD by Regulating HMGB1
[Experimental Cell Research] Researchers investigated the molecular mechanism underlying the effect of OTUB1 on regulating nonalcoholic fatty liver disease.
MRPL24 Drives Breast Cancer Metastasis and Stemness by Targeting C-MYC, BRD4, and STAT3
Investigators explored the clinicopathological significance of MRPL24 in human cancers, with a particular focus on breast cancer.
[3 Biotech] Abstract
FSD1 Inhibits Glioblastoma Diffuse Infiltration Through Restriction of HDAC6-Mediated Microtubule Deacetylation
[Science China Life Sciences] Investigators increased expression of fibronectin type III and SPRY domain-containing 1 (FSD1) or interference with FSD1 phosphorylation reduces microtubule deacetylation, suppresses invasion of glioblastoma (GBM) stem cells, and ultimately mitigates tumor infiltration in orthotopic GBM xenografts.
AGD1/USP10/METTL13 Complexes Enhance Cancer Stem Cells Proliferation and Diminish the Therapeutic Effect of Docetaxel via CD44 m6A Modification in Castration Resistant Prostate Cancer
[Journal of Experimental & Clinical Cancer Research] The authors demonstrated that AGD1, derived from prostate cancer stem cells, enhanced the stemness of prostate cancer cells and reduced the therapeutic effect of docetaxel in castration-resistant prostate cancer.
Single-cell Transcriptomics Reveals Intratumor Heterogeneity and the Potential Roles of Cancer Stem Cells and myCAFs in Colorectal Cancer Liver Metastasis and Recurrence
[Cancer Letters] Investigators identified a cancer cell subpopulation termed stem/transient amplifying-like cells, which expressed genes associated with stem cell-like characteristics and metastatic potential.
Insights Into the Role of Bmi-1 Deregulation in Promoting Stemness and Therapy Resistance in Glioblastoma: A Narrative Review
Bmi-1 regulates self-renewal, proliferation, and differentiation of GBM cells, promoting stemness and therapy resistance. The authors discuss the importance of targeting Bmi-1 which could...
Eterna Therapeutics Announces Positive Preclinical Study Results on Lead Product ERNA-101 in Ovarian Cancer
Eterna Therapeutics announced positive results from a preclinical study on the company’s lead cell therapy product, ERNA-101, which is designed to activate and regulate...
LncRNA FGD5-AS1 Facilitates Hepatocellular Carcinoma Cell Stemness by Enhancing PKD1 mRNA Stability through Binding With MSI2
Both musashi 2 (MSI2) and protein kinase D1 (PKD1) ameliorated short hairpin-long noncoding RNA FGD5 antisense RNA 1's inhibition of hepatocellular carcinoma cell viability,...
Raddeanin A (RA) Inhibited EMT and Stemness in Glioblastoma via downregulating Skp2
[Journal of Cancer] Scientists elucidated Raddeanin A's significant antitumor efficacy against glioblastoma in vitro and in vivo by targeting pathways linked to stemness and epithelial-mesenchymal transition, chiefly via the downregulation of S phase kinase-associated protein 2 (Skp2).
Prognostic Model Based on Tumor Stemness Genes for Triple-Negative Breast Cancer
[Scientific Reports] Researchers developed a prognostic model based on triple-negative breast cancer (TNBC) tumor stemness cell marker genes, which has a good ability to predict the prognosis of TNBC patients and the effect of response to drug therapy.
N6-Methyladenosine-Modified Long Non-Coding RNA KIF9-AS1 Promotes Stemness and Sorafenib Resistance in Hepatocellular Carcinoma by Upregulating SHOX2 Expression
[World Journal of Gastroenterology] Investigators described the role of the lncRNA KIF9-AS1 in cancer stemness and drug resistance in hepatocellular carcinoma and elucidated the underlying mechanism.
Nicotine Enhances the Stemness and Tumorigenicity in Intestinal Stem Cells via Hippo-YAP/TAZ and Notch Signal Pathway
[eLife] Researchers identified a nicotine-triggered pathway regulating the stemness and tumorigenicity of intestinal stem cells and suggested the use of dibenzazepine as a potential therapeutic strategy for treating intestinal tumors.
Cancer Stem Cell News consolidates the most recent publications covering research areas such as the identification and isolation of cancer stem cells, their proliferation and differentiation characteristics, gene expression and regulatory pathways, and the development of anti-cancer therapies. We also include cancer stem cell jobs and events hosted by leading research organizations, societies, and institutes.
