Noshin Noorjahan

ESC & iPSC News

Generation and Validation of an iPSC Line (BBANTWi008-a) from a Loeys-Dietz Syndrome Type 3 Patient

[Stem Cell Research] Researchers generated an iPSC line of a severely affected Loeys-Dietz Syndrome patient carrying a pathogenic SMAD3 p.Arg287Gln variant. Peripheral blood mononuclear cells were reprogrammed using non-integrating Sendai viral vectors.

ESC & iPSC News

Prdm14 Promotes Mouse ESC Self-Renewal and PGCLC Specification through Enhancement of Stat3 Activity

[iScience] Using high-throughput sequencing, chromatin immunoprecipitation and luciferase reporter assays, scientists showed that Prdm14 directly bound to the promoter of Socs3 and repressed its transcription to increase the phosphorylation level of Stat3 protein.

ESC & iPSC News

Generation of Induced Pluripotent Stem Cell (iPSC) from NY-ESO-I-Specific Cytotoxic T Cells Isolated from the Melanoma Patient with Minor HLAs: The Practical Pilot Study...

[Experimental Dermatology] Investigators monoclonally isolated CD8+ T cells specifically reactive with NY-ESO-1 from the melanoma patient’s monocytes after stimulated with NY-ESO-1 peptide by manual procedure, and cultured NY-ESO-1-specific TCs until proliferated and formed colonies.

ESC & iPSC News

Autophagy and Pluripotency: Self-Eating Your Way to Eternal Youth

[Trends in Cell Biology] The authors review recent literature on the mechanistic role of different types of autophagy in embryonic development, ESCs, and iPSCs, focusing on their remodeling functions on protein, metabolism, and epigenetics.

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Screening the Human miRNA Interactome Reveals Coordinated Up-Regulation in Melanoma, Adding Bidirectional Regulation to miRNA Networks

[Science Advances] Researchers demonstrated coordinated up-regulation of functionally coupled proteins by miRNA. They focused on CD98 heavy chain (CD98hc), the heavy chain of the amino acid transporter LAT-1, and α-2,3-sialyltransferases ST3GAL1 and ST3GAL2, which were critical for CD98hc stability in melanoma.

Perivascular Cells Function as Key Mediators of Mechanical and Structural Changes in Vascular Capillaries

[Science Advances] Researchers used a microphysiological model of capillaries on a chip mimicking the characteristics of healthy or fibrotic collagen to test the hypothesis that perivascular cells mediated the response of vascular capillaries to mechanical and structural changes in the human ECM.

IRE1α–XBP1 Safeguards Hematopoietic Stem and Progenitor Cells by Restricting Pro-Leukemogenic Gene Programs

[Nature Immunology] Investigators uncovered unfolded protein response stress sensor inositol-requiring enzyme-1α (IRE1α) signaling in hematopoietic stem and progenitor cells as a safeguard against myeloid leukemogenesis.

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Noshin Noorjahan

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