Noshin Noorjahan

[Circulation Research] The authors discuss novel and alternative approaches to blood vessel engineering and explore the cellular identity of engineered blood vessels in comparison to in vivo vasculature.

[Developmental Dynamics] Investigators discuss the cohort of transcription factors known to be involved in directing gene expression during different stages of mammalian vasculogenesis and angiogenesis with a primary focus on development.

[npj Precision Oncology] Scientists reported that knockdown, forced overexpression, and pharmacologic inhibition of angiotensin I-converting enzyme 2 (ACE2) in human colon cancer cells targeted (ACE2)-BRD4 crosstalk to mediate marked changes in DNA damage/repair and apoptosis.

[Cell Death & Disease] Investigators found that overexpression of miR-17-5p led to less apoptosis and lower drug sensitivity in vitro and in vivo under the 5-fluorouracil (5-FU) treatment, which indicated miR-17-5p led to 5-FU chemotherapy resistance.

[Cell Death & Disease] Ibrutinib sensitized colorectal cancer (CRC) to ferroptosis inducers, suggested by reduced CRC cell viability, proliferation, and decreased antioxidant protein levels in CRC cells after combination treatment of Ibrutinib and RSL3 or Ibrutinib and Erastin both in vivo and in vitro.

[JCI Insight] Researchers identified an EGF family member, EPIREGULIN (EREG), which was robustly expressed in the developing human crypt. Enteroids generated from the developing human intestine grown in standard culture conditions were dominated by stem and progenitor cells, featureed little differentiation and no spatial organization.