Noshin Noorjahan

[eLife] Through single-cell RNA sequencing of non-neuronal cell populations of the murine cerebral cortex, investigators identified reactive endothelial venules, a compartment of specialized postcapillary endothelial cells.

[Scientific Reports] The authors investigated the effects of intermittent hypoxia and epinephrine on gene expression in human aortic endothelial cells using RNA-sequencing.

[Nature Cardiovascular Research] Scientists found that estrogen regulated blood vessel physiology during pregnancy and menopause through estrogen receptor alpha (ERα) and G-protein-coupled estrogen receptor-1 but not ERβ-dependent signaling in mice.

[Nature Reviews Cardiology] Researchers describe the latest findings in vascular endothelial cell development and diversity, which are often supported by large-scale, single-cell studies, and discuss the implications of these findings for vascular medicine.

[Cardiovascular Drugs and Therapy] The authors summarise the widely used methods of exposing cultured endothelium to fluid shear stress (FSS), the flow profile they generate and their advantages and limitations in investigating the pathological contribution of altered FSS to vascular disease.

[Novartis Pharma AG] Novartis announced that the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) has recommended granting a marketing authorization for Pluvicto, a radioligand therapy, for the treatment of adult patients with progressive, PSMA-positive metastatic castration-resistant prostate cancer.