Noshin Noorjahan

Endothelial Cell News

Single-Cell Spatial Transcriptomics Reveals a Dynamic Control of Metabolic Zonation and Liver Regeneration by Endothelial Cell Wnt2 and Wnt9b

[Cell Reports Medicine] Using single-cell analysis, scientists identified a conserved Wnt2 and Wnt9b expression in endothelial cells in zone 3.

Endothelial Cell News

Sox17 Deficiency Promotes Pulmonary Arterial Hypertension via HGF (Hepatocyte Grow Factor)/c-Met Signaling

[Circulation Research] In adult mice, Sox17 deletion in pulmonary endothelial cells induced pulmonary arterial hypertension under hypoxia with high penetrance and severity, but not under normoxia.

Endothelial Cell News

Endothelial Cell Cycle State Determines Propensity for Arterial-Venous Fate

[Nature Communications] Using Cdh5-CreERT2;R26FUCCI2aR reporter mice, investigators found that venous endothelial cells were enriched for the FUCCI-Negative state (early G1) and BMP signaling, while arterial endothelial cells were enriched for the FUCCI-Red state (late G1) and TGF-β signaling.

Endothelial Cell News

Competition for Endothelial Cell Polarity Drives Vascular Morphogenesis in the Mouse Retina

[Developmental Cell] Researchers demonstrated that the competition between biochemical and mechanical cues controlled the shift of collective front-to-rear polarity of endothelial cells in the mouse retina.

Endothelial Cell News

Endothelial RBPJ Is Essential for the Education of Tumor-Associated Macrophages

[Cancer Research] The authors reported that canonical Notch signaling through RBPJ in endothelial cells was an important player in the education of tumor-associated macrophages and epithelial ovarian cancer progression.

Endothelial Cell News

Acute Pharmacological Degradation of ERK5 Does Not Inhibit Cellular Immune Response or Proliferation

[Cell Chemical Biology] To investigate potential non-catalytic functions of ERK5, scientists reported the development of INY-06-061, a potent and selective heterobifunctional degrader of ERK5.

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Human Hair Follicle Mesenchymal Stem Cell-Derived Exosomes Attenuate UVB-Induced Photoaging via the miR-125b-5p/TGF-β1/Smad Axis

[Biomaterials Research] The authors revealed that exosomes derived from human hair follicle mesenchymal stem cells effectively enhanced the migration and proliferation of human dermal fibroblasts (HDFs) and upregulated the expressions of TGF-β1, p-Smad2/p-Smad3, collagen type 1, and collagen type 3.

CPSF6-RARγ Interacts with Histone Deacetylase 3 to Promote Myeloid Transformation in RARG-Fusion Acute Myeloid Leukemia

[Nature Communications] Using the most prevalent retinoic acid receptor gamma (RARG) fusion, CPSF6-RARG (CR), as a representative, scientists revealed that the CR fusion, enhanced the expansion of myeloid progenitors, impaired their maturation and synergized with RAS mutations to drive more aggressive myeloid malignancies.

Reduced Circulating Sphingolipids and CERS2 Activity Are Linked to T2D Risk and Impaired Insulin Secretion

[Science Advances] Researchers examined whole-body ceramide synthase 2 (Cers2) knockout and rs267738 knock-in mice. Both models exhibited glucose intolerance and impaired insulin secretion in vivo. Islets isolated from these models also demonstrated reduced β cell function, as shown by decreased insulin secretion ex vivo.

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Noshin Noorjahan

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