All Articles by Author:

Noshin Noorjahan

A Method for Stabilizing the XX Karyotype in Female mESC Cultures

[Development] Scientists reported a method for better maintaining XX female mESCs in culture, which also stabilized the male karyotype, and made study of female specific pluripotency more feasible.

Effect of Exposure to Ionizing Radiation on Competitive Proliferation and Differentiation of hESC

[International Journal of Radiation Biology] To study the competitive proliferation and differentiation of hESCs, researchers obtained cells of H9 hESC line that stably expressed green fluorescent protein.

Regulatory Mechanism and Biological Function of UHRF1–DNMT1-Mediated DNA Methylation

[Functional & Integrative Genomics] The author describes the whole molecular process of UHRF1–DNMT1 pathway and lists some latest biological research progress related to this pathway in the development of early embryonic, maintenance of pluripotency of embryonic stem cells, regulation of expression of imprinted genes, inactivation of X chromosome, and development of cancer.

A Wesleyan Scientist Is Searching for the ‘First Moment’ When Alzheimer’s Hits the Brain

[Connecticut Public] Wesleyan University received $1.7 million in early-stage funding from the National Institutes of Health to find an answer to an urgent question: “What’s the first thing that goes wrong, that snowballs into the pathology that we see later in Alzheimer’s disease?”.

Glucagon-Like Peptide-1 Receptor Tie2+ Cells Are Essential for the Cardioprotective Actions of Liraglutide in Mice with Experimental Myocardial Infarction

[Molecular Metabolism] Publicly available single cell RNA sequencing datasets on mouse and human heart cells were analyzed for Glp1r/GLP1R expression. Fluorescent activated cell sorting was used to localize Glp1r expression in cell populations from the mouse heart.

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Screening the Human miRNA Interactome Reveals Coordinated Up-Regulation in Melanoma, Adding Bidirectional Regulation to miRNA Networks

[Science Advances] Researchers demonstrated coordinated up-regulation of functionally coupled proteins by miRNA. They focused on CD98 heavy chain (CD98hc), the heavy chain of the amino acid transporter LAT-1, and α-2,3-sialyltransferases ST3GAL1 and ST3GAL2, which were critical for CD98hc stability in melanoma.

Perivascular Cells Function as Key Mediators of Mechanical and Structural Changes in Vascular Capillaries

[Science Advances] Researchers used a microphysiological model of capillaries on a chip mimicking the characteristics of healthy or fibrotic collagen to test the hypothesis that perivascular cells mediated the response of vascular capillaries to mechanical and structural changes in the human ECM.

IRE1α–XBP1 Safeguards Hematopoietic Stem and Progenitor Cells by Restricting Pro-Leukemogenic Gene Programs

[Nature Immunology] Investigators uncovered unfolded protein response stress sensor inositol-requiring enzyme-1α (IRE1α) signaling in hematopoietic stem and progenitor cells as a safeguard against myeloid leukemogenesis.