Noshin Noorjahan

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Stromal FOXF2 Suppresses Prostate Cancer Progression and Metastasis by Enhancing Antitumor Immunity

[Nature Communications] Researchers showed that increasing prostatic stromal Foxf2 suppressed the growth and progression of both syngeneic and autochthonous mouse prostate cancer models in an immunocompetent context.

Endothelial Cell News

Suppression of CCL2 Angiocrine Function by Adrenomedullin Promotes Tumor Growth

[Journal of Experimental Medicine] The authors reported that tumor cell-derived adrenomedullin had a pro-angiogenic as well as a direct tumor-promoting effect, and that endothelium-derived CC chemokine ligand 2 (CCL2) suppressed adrenomedullin-induced tumor cell proliferation.

Endothelial Cell News

Vascular Endothelium Deploys Caveolin-1 to Regulate Oligodendrogenesis after Chronic Cerebral Ischemia in Mice

[Nature Communications] Using a mouse of bilateral carotid artery stenosis, researchers showed a gradual accumulation of oligodendrocyte precursor cells on vasculature with impaired oligodendrogenesis.

Endothelial Cell News

Flash Drug Release from Nanoparticles Accumulated in the Targeted Blood Vessels Facilitates the Tumor Treatment

[Nature Communications] Investigators introduced an anticancer drug delivery concept termed FlaRE (Flash Release in Endothelium), which represented an alternative to the existing approaches based on enhanced permeability and retention effect.

Endothelial Cell News

Activating NO-sGC Crosstalk in the Mouse Vascular Niche Promotes Vascular Integrity and Mitigates Acute Lung Injury

[Journal of Experimental Medicine] Using comparative genome-wide endothelial cell-pericyte crosstalk analysis of healthy and LPS-challenged lungs, scientists discovered that crosstalk between endothelial nitric oxide and pericyte soluble guanylate cyclase (NO-sGC) was impaired in acute lung injury.

Endothelial Cell News

Aging Results in DNA Damage and Telomere Dysfunction That Is Greater in Endothelial versus Vascular Smooth Muscle Cells and Is Exacerbated in Atheroprone Regions

[GeroScience] Researchers studied the effect of aging on arterial DNA damage and telomere dysfunction. Aging resulted in greater DNA damage in endothelial cells than in vascular smooth muscle cells.

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Survival Outcomes of Apalutamide as a Starting Treatment: Impact in Real-World Patients With Metastatic Hormone Sensitive Prostate Cancer (OASIS)

[Prostate Cancer and Prostatic Diseases] Scientists evaluated the impact of upfront therapy for metastatic hormone-sensitive prostate cancer on outcomes in real-world clinical practice in the United States.

A TBX2-Driven Signaling Switch From Androgen Receptor to Glucocorticoid Receptor Confers Therapeutic Resistance in Prostate Cancer

[Oncogene] Using human prostate cancer and CRPC cell line models, scientists demonstrated that TBX2 downregulated androgen receptor and upregulated glucocorticoid receptor through direct transcriptional regulation.

Radiotherapy-Resistant Prostate Cancer Cells Escape Immune Checkpoint Blockade through the Senescence-Related Ataxia Telangiectasia and Rad3-Related Protein

[Cancer Communications] Scientists identified a subset of prostate cancer cells that exhibited resistance to radiotherapy, characterized by a reduced antigen presentation capability, which enhanced their ability to evade immune detection and resist cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) blockade.

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Noshin Noorjahan

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