Noshin Noorjahan

[Nature] A fundamental challenge for cancer vaccines is to generate long-lived functional T cells that are specific for tumor antigens. Investigators found that mRNA–lipoplex vaccines against somatic mutation-derived neoantigens may solve this challenge in pancreatic ductal adenocarcinoma.

[Gene Therapy] scAAV1.tMCK.NT-3 was delivered to the gastrocnemius muscle of experimental autoimmune encephalomyelitis (EAE) mice, the chronic relapsing mouse model of multiple sclerosis, at three weeks post EAE induction.

[eLife] Researchers constructed a live-attenuated vaccine candidate, BK2102, combining naturally occurring virulence-attenuating mutations in the NSP14, NSP1, spike, and ORF7-8 coding regions.

[Journal of Virology] To understand how Tfh/GC B-cell interactions during acute HIV-1 infection (AHI) impact the generation of HIV-specific antibodies, researchers performed a unique cross-sectional analysis of inguinal lymph node biopsies taken prior to antiretroviral therapy initiation in AHI.

[Infection and Immunity] The authors reported that mutations in mitochondria DNA polymerase gamma potentiate susceptibility to Mycobacterium tuberculosis infection in mice.

[Microbiology Spectrum] Scientists determined the association between neutralizing antibody responses, inflammation, and clinical outcomes in hospitalized patients with COVID-19.