Noshin Noorjahan

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Intranasal Dupilumab Improves Responsiveness to Steroid in an Asthma Mouse Model

[Inflammation Research] Dupilumab was administered via both intranasal and intraperitoneal routes to a mouse model of steroid-hyporesponsive asthma.

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SMARCB1-Driven EGFR-GLI1 Epigenetic Alterations in Lung Cancer Progression and Therapy Are Differentially Modulated by MEOX2 and GLI-1

[Cancer Gene Therapy] Scientists revealed how MEOX2 and GLI-1 are key molecular modulators of the GLI-1 and EGFR-epigenetic patterns, which in turn transcriptionally and epigenetically affected EGFR gene expression in lung cancer.

Newsletters

The Direct and Indirect Role of IgE on Airway Epithelium in Asthma

[Allergy] The authors discuss the indirect and direct roles of immunoglobulin E (IgE) on airway epithelial cells, with a focus on allergic asthma disease.

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Boehringer’s Zongertinib Receives Priority Review from US FDA for the Treatment of HER2 (ERBB2)-Mutant Advanced Non-Small Cell Lung Cancer

[Boehringer Ingelheim] Boehringer Ingelheim announced that the US FDA has granted Priority Review to its new drug application for zongertinib for the treatment of adult patients with unresectable or metastatic NSCLC whose tumors have HER2 mutations and who have received prior systemic therapy.

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β Cell Dedifferentiation, the Underlying Mechanism of Diabetes in Wolfram Syndrome

[Science Translational Medicine] Researchers indicated loss of β cell lineage and subsequent dedifferentiation as the mechanisms underlying functional and mass deficits in Wolfram syndrome.

Endothelial Cell News

Lymphatic Transport in Anti-Tumor Immunity and Metastasis

[Journal of Experimental Medicine] Investigators review the involvement of lymphatic vessels s in tumor progression, metastasis, and modulation of anti-tumor immune response.

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Doublecortin Restricts Neuronal Branching by Regulating Tubulin Polyglutamylation

[Nature Communications] Researchers used CRISPR/Cas9 to knock-out the Doublecortin gene in iPSCs and differentiated the cells into cortical neurons. DCX-KO neurons showed reduced velocities of nuclear movements and an increased number of neurites early in neuronal development.

Pluristyx Enables Safer, Universal Cell Therapy Solutions with Newly Issued US Patent for iACT Stealth™ Technology

[Pluristyx] Pluristyx announced the issuance of the induced Allogeneic Cell Tolerance (iACT Stealth™) US Patent No. 12,178,835. This patent marks a significant milestone in Pluristyx's mission to bring advanced cell therapy solutions to the global market.

Bahrain Makes History with First Successful CRISPR-Based Sickle Cell Treatment Outside the US

[The Canadian Press] The Bahrain Oncology Centre has made medical history by successfully treating a sickle cell disease patient using CRISPR-based gene-editing therapy, Casgevy. This marks the first successful treatment of its kind outside the United States.

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Noshin Noorjahan

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