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Pulmonary Cell NewsAll Articles by Author:
Noshin Noorjahan
ESC & iPSC News
Pluripotency Factors Are Repurposed to Shape the Epigenomic Landscape of Neural Crest Cells
[Developmental Cell] By assessing avian and human neural crest cells at distinct developmental stages, scientists characterized the epigenomic changes that occured during their specification, migration, and early differentiation.
ESC & iPSC News
Acoustically Accelerated Neural Differentiation of Human Embryonic Stem Cells
[Acta Biomaterialia] To accelerate the neuron production from hESCs, an acoustic stimulator producing surface acoustic waves was proposed and realized by clamping a flexible printed circuit board directly onto a piezoelectric substrate.
ESC & iPSC News
In Vivo Generation of Bone Marrow from Embryonic Stem Cells in Interspecies Chimeras
[eLife] Based on FACS analysis and single-cell RNA sequencing, mESCs differentiated into multiple hematopoietic and stromal cell types that were indistinguishable from normal mouse bone marrow cells.
ESC & iPSC News
The Centrosomal Protein 83 (CEP83) Regulates Human Pluripotent Stem Cell Differentiation towards the Kidney Lineage
[eLife] The authors induced inactivating deletions of CEP83 in hiPSCs and applied a 7 day in vitro protocol of intermediate mesoderm kidney progenitor differentiation, based on timed application of WNT and FGF agonists.
ESC & iPSC News
Human Embryonic Stem Cell-Specific Role of YAP in Maintenance of Self-Renewal and Survival
[Cellular and Molecular Life Sciences] Investigators demonstrated that yes-associated protein functioned in an hESC-specific manner to maintain self-renewal and survival in hESCs. hESCs were highly sensitive to YAP downregulation to promote cell survival.
ESC & iPSC News
Generation and Validation of an iPSC Line (BBANTWi008-a) from a Loeys-Dietz Syndrome Type 3 Patient
[Stem Cell Research] Researchers generated an iPSC line of a severely affected Loeys-Dietz Syndrome patient carrying a pathogenic SMAD3 p.Arg287Gln variant. Peripheral blood mononuclear cells were reprogrammed using non-integrating Sendai viral vectors.
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CHIKV mRNA Vaccines Encoding Conserved Structural/Envelope Proteins Confer Broad Cross-Lineage Protection against Infection
[Signal Transduction and Targeted Therapy] Scientists designed chikungunya virus (CHIKV) mRNA vaccines containing full-length structural proteins or part of structural proteins based on conserved sequences from 769 viral strains encompassing four lineages.
T Cell-Derived IFN-γ Suppresses T Follicular Helper Cell Differentiation and Antibody Responses
[EMBO Journal] Researchers showed that T-bet+ cells induced by lymphocytic choriomeningitis virus infection encompassed a TH1 cell subset expressing granzyme B and a Tcf-1+ cell subset that retained the potential for T follicular helper (TFH) differentiation without expressing mature TFH markers.
Distinct Type 1 Immune Networks Underlie the Severity of Restrictive Lung Disease after COVID-19
[Nature Immunology] Scientists analyzed hundreds of cellular and molecular features in the context of discrete pulmonary phenotypes to define the systemic immune landscape of post-COVID lung disease.
