Noshin Noorjahan

Newsletters

Prostate Cancer: Genetics in Practice Now and in the Future

[Hereditary Cancer in Clinical Practice] The authors write a mini review of how the genetics of prostate cancer can impact on screening and early detection of the disease and the treatment and management of the disease when diagnosed.

Neural Cell News

The Postsynaptic Density in Excitatory Synapses Is Composed of Clustered, Heterogeneous Nanoblocks

[Journal of Cell Biology] Scientists used cryo-electron tomography to directly visualize the three-dimensional architecture and supramolecular organization of postsynaptic components in both synaptosomes and synapses from cultured neurons.

Neural Cell News

PI3Kβ Functions As a Protein Kinase to Promote Cellular Protein O-GlcNAcylation and Acetyl-CoA Production for Tumor Growth

[Molecular Cell] Investigators demonstrate that high glucose induces PI3Kβ binding to O-linked β-D-N-acetylglucosamine (O-GlcNAc) transferase (OGT) in glioblastoma cells, dependent on hexokinase 1-mediated OGT Y889 phosphorylation and subsequent p85α recruitment.

Cell Therapy News

The Clinical Landscape of CAR NK Cells

[Experimental Hematology & Oncology] The authors explore the current clinical landscape of CAR NK cells, and their application in hematologic malignancies and solid cancers, as well as their potential for treating autoimmune disorders.

Cell Therapy News

Clinical Development of Therapeutic mRNA Applications

[Molecular Therapy] Researchers discuss examples of mRNA therapeutics currently in clinical trials within each category, providing a comprehensive overview of the field's progress and highlighting key advancements as of the end of 2024.

Newsletters

Amplified Dosage of the NKX2-1 Lineage Transcription Factor Controls Its Oncogenic Role in Lung Adenocarcinoma

[Molecular Cell] Investigators found that the most significant focal amplification event in lung adenocarcinoma (LUAD) targeted a lineage “super-enhancer” near the NKX2-1 lineage transcription factor.

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The Histone Modifier KAT2A Presents a Selective Target in a Subset of Well-Differentiated Microsatellite-Stable Colorectal Cancers

[Cell Death & Differentiation] Investigators elucidated the molecular underpinnings of lysine acetyltransferase 2 A (KAT2A) dependency in CRC and assessed the consequences of KAT2A depletion.

Diosmin Alleviates Colitis by Inhibiting PANoptosis of Intestinal Epithelial Cells and Regulating Gut Microbiota and Metabolites

[Phytomedicine] Scientists investigate the therapeutic efficacy and mechanistic underpinnings of diosmin in dextran sulfate sodium-induced colitis, with a focus on its effects on intestinal epithelial cell PANoptosis, gut microbiota composition, fecal metabolites, and an in vitro inflammatory model using human colonic epithelial cells.

Effects of 1,3-Dioleoyl-2-palmitoylglycerol on Intestine Structural and Functional Development in Early Life

[Molecular Nutrition & Food Research] Researchers explored the effects of 1,3-Dioleoyl-2-palmitoyl-glycerol on intestinal epithelial structure and barrier construction in neonatal mice and the involvement of intestinal microorganisms.

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Noshin Noorjahan

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