All Articles by Author:

Noshin Noorjahan

Catalpol Regulates Apoptosis and Proliferation of Endothelial Cell via Activating HIF-1α/VEGF Signaling Pathway

[Scientific Reports] Scientists investigated whether Catalpol regulated apoptosis and proliferation following vascular injury induced by burns using an in vitro model of oxygen-glucose deprivation with a HUVEC line.

Extracellular Vesicles Derived from Endothelial Progenitor Cells Modified by Houshiheisan Promote Angiogenesis and Attenuate Cerebral Ischemic Injury via miR-126/PIK3R2

[Scientific Reports] Researchers investigated the impact of Houshiheisan-modified xtracellular vesicles-derived extracellular vesicles on angiogenesis using rats with permanent middle cerebral artery occlusion and brain microvascular endothelial cells subjected to oxygen-glucose deprivation.

SIRT3 Deficiency Promotes Lung Endothelial Pyroptosis through Impairing Mitophagy to Activate NLRP3 Inflammasome during Sepsis-Induced Acute Lung Injury

[Molecular and Cellular Biology] Scientists investigated the effects of sirtuin 3 deficiency on impaired mitophagy to promote lung endothelial cell pyroptosis during sepsis-induced acute lung injury.

Sandoz Receives European Commission Approval for Afqlir® (Aflibercept), Further Strengthening Leading Biosimilar Portfolio

[Sandoz] Sandoz announced that the European Commission has granted marketing authorization for Afqlir® 2 mg vial kit and pre-filled syringe for intravitreal injection. Afqlir® is indicated to treat various retinal diseases, including neovascular age-related macular degeneration.

AlveoGene Receives Rare Pediatric Disease Designation (RPDD) from FDA for AVG-002, Its Novel, Inhaled Gene Therapy for Lethal Neonatal Surfactant Protein B (SP-B) Deficiency

[AlveoGene] AlveoGene announced that it has been granted a RPDD by the US FDA for AVG-002, its novel inhaled gene therapy for lethal neonatal SP-B deficiency.

Endothelial Heterogeneity in Bone Marrow: Insights Across Development, Adult Life, and Leukemia

[Leukemia] The authors highlight key milestones and recent advances in understanding vascular heterogeneity within bone marrow microenvironment during development, adulthood, and aging.

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Bilayered Skin Equivalent Mimicking Psoriasis as Predictive Tool for Preclinical Treatment Studies

[Communications Biology] Scientists focused on treatment responses of 3D skin replicas. Cytokine-priming of skin organoids induced psoriatic features like inflammation, antimicrobial peptides, hyperproliferation, and impaired differentiation.

Mechanistic Basis of Atypical TERT Promoter Mutations

[Nature Communications] Atypical telomerase reverse transcriptase promoter (TERTp) mutations occured with canonical driver mutations in large cancer cohorts and arose subclonally specifically on the TERTp driver mutant chromosome homolog of melanoma cells treated with UV light in vitro.

Exploring Human Pancreatic Organoid Modelling Through Single-Cell RNA Sequencing Analysis

[Communications Biology] Using single-cell RNA sequencing, researchers generated a comprehensive molecular atlas, describing human pancreatic organoids derived from human islet-depleted pancreatic tissue.