Noshin Noorjahan

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RTN3 Regulates Collagen Biosynthesis and Profibrotic Macrophage Differentiation to Promote Pulmonary Fibrosis via Interacting with CRTH2

[Molecular Medicine] Scientists explored the role of reticulum 3 (RTN3) in pulmonary fibrosis using public datasets, idiopathic pulmonary fibrosis patient samples, and animal models. They investigated its pathogenic mechanisms in lung fibroblasts and alveolar macrophages.

Neural Cell News

Targeting cIAP2 in a Novel Senolytic Strategy Prevents Glioblastoma Recurrence after Radiotherapy

[EMBO Molecular Medicine] The authors reported that ionizing radiation-induced senescence of tumor cells counterintuitively spurred glioblastoma recurrence, driven by the senescence-associated secretory phenotype.

Neural Cell News

Neuronal FAM171A2 Mediates α-synuclein Fibril Uptake and Drives Parkinson’S Disease

[Science] Researchers identified FAM171A2 as a Parkinson's disease risk gene that affected α-syn aggregation. Overexpressing FAM171A2 promoted α-syn fibril endocytosis and exacerbated the spread and neurotoxicity of α-syn pathology.

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Human Midbrain Organoids Enriched with Dopaminergic Neurons for Long-Term Functional Evaluation

[Cell Proliferation] The authors presented an innovative approach that combined developmental patterning with mechanical cutting to produce small midbrain organoids, with diameters less than 300 μm, suitable for long-term evaluation.

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Unravelling Genotype-Phenotype Correlations in Stargardt Disease Using Patient-Derived Retinal Organoids

[Cell Death & Disease] To investigate the cellular and molecular characteristics associated with Stargardt disease (STGD1), researchers generated iPSCs from two monoallelic unresolved, late-onset STGD1 cases with the heterozygous complex allele - c.[5461-10 T > C;5603 A > T].

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Organoid Models to Study Human Infectious Diseases

[Cell Proliferation] Investigators briefly introduce the development of organoids, focusing on historically significant infectious diseases that have caused fatal harm to human health, such as HIV, ZIKV, SARS-CoV-2 and MPXV.

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Doublecortin Restricts Neuronal Branching by Regulating Tubulin Polyglutamylation

[Nature Communications] Researchers used CRISPR/Cas9 to knock-out the Doublecortin gene in iPSCs and differentiated the cells into cortical neurons. DCX-KO neurons showed reduced velocities of nuclear movements and an increased number of neurites early in neuronal development.

Pluristyx Enables Safer, Universal Cell Therapy Solutions with Newly Issued US Patent for iACT Stealth™ Technology

[Pluristyx] Pluristyx announced the issuance of the induced Allogeneic Cell Tolerance (iACT Stealth™) US Patent No. 12,178,835. This patent marks a significant milestone in Pluristyx's mission to bring advanced cell therapy solutions to the global market.

Bahrain Makes History with First Successful CRISPR-Based Sickle Cell Treatment Outside the US

[The Canadian Press] The Bahrain Oncology Centre has made medical history by successfully treating a sickle cell disease patient using CRISPR-based gene-editing therapy, Casgevy. This marks the first successful treatment of its kind outside the United States.

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Noshin Noorjahan

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