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Hematopoiesis News

Combining Nilotinib and PD-L1 Blockade Reverses CD4+ T Cell Dysfunction and Prevents Relapse in Acute B-cell Leukemia

[Blood] Single-cell RNA-sequence analysis revealed that B-ALL induces a unique subset of CD4+ T cells with both cytotoxic and helper functions.

Hematopoiesis News

Predictive Factors and Outcomes After Allogeneic Stem-Cell Transplantation for Adults with Acute Lymphoblastic Leukemia in Brazil

[Transplantation and Cellular Therapy ] Investigators described outcomes and examine risk factors for overall survival, leukemia-free survival, cumulative incidence of relapse, non-relapse mortality and graft-versus-host disease after allogeneic stem-cell transplantation for acute lymphoblastic leukemia in Brazilian centers.

Hematopoiesis News

B Cell Antigen Receptor Expression and Phosphatidylinositol 3-Kinase Signaling Regulate Genesis and Maintenance of Mouse Chronic Lymphocytic Leukemia

[Haematologica] By ablating the B cell antigen receptor in chronic lymphocytic leukemia (CLL) cells from TCL1 transgenic mice, the authors showed that CLL cells cannot survive without BCR signaling and are lost within eight weeks in diseased mice.

Hematopoiesis News

Sorting Nexin 24 Is Required for α-Granule Biogenesis and Cargo Delivery in Megakaryocytes

[Haematologica] The authors investigated whether the genes showing abnormal expression in FLI1-deficient platelets could be involved in platelet α-granule biogenesis by undertaking transcriptome analysis of control platelets and platelets harboring a DNA-binding variant of FLI1.

Hematopoiesis News

Platelet-Inspired Intravenous Nanomedicine for Injury-Targeted Direct Delivery of Thrombin to Augment Hemostasis in Coagulopathies

[ACS Nano] Scientists reported on the design and evaluation of thrombin-loaded injury-site-targeted lipid nanoparticles that could specifically localize at an injury site via platelet-mimetic anchorage to the von Willebrand factor and collagen.

Hematopoiesis News

Fate Mapping of Hematopoietic Stem Cells Reveals Two Pathways of Native Thrombopoiesis

[Nature Communications] Researchers chart native lineage pathways emanating from HSCs and define their physiological regulation by computationally integrating experimental approaches for fate mapping, mitotic tracking, and single-cell RNA sequencing.

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The Vps13-Like Protein BLTP2 Regulates Phosphatidylethanolamine Levels to Maintain Plasma Membrane Fluidity and Breast Cancer Aggressiveness

[Nature Cell Biology] Scientists found that bridge-like lipid transport proteins (BLTPs) facilitated the growth of a triple-negative breast cancer cell line and sustained its aggressiveness in an in vivo model of metastasis, suggesting that maintenance of plasma membrane fluidity by BLTP2 may be critical for tumorigenesis in humans.

Autophagy-Targeted NBR1-P62/SQSTM1 Complexes Promote Breast Cancer Metastasis by Sequestering ITCH

[Nature Cell Biology] Investigators showed that autophagy normally suppresses breast cancer metastasis by enabling the clearance of NBR1–p62/SQSTM1 complexes that instruct p63-mediated pro-metastatic basal differentiation programs.

p95HER2, a Truncated Form of the HER2 Oncoprotein, Drives an Immunosuppressive Program in HER2 Breast Cancer That Limits Trastuzumab Deruxtecan Efficacy

[Nature Cancer] Researchers demonstrated that p95HER2, a truncated form of human epidermal growth factor receptor 2 (HER2), drives immune evasion in HER2-positive female breast cancer, enhancing tumor growth and conferring therapy resistance.

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