Laurisa Dohm

Hematopoiesis News

Endocardium Gives Rise to Blood Cells in Zebrafish Embryos

[Cell Reports] Using a combination of expression analysis, time-lapse imaging, and lineage-tracing approaches, investigators demonstrated that myeloid cells emerged from the endocardium in zebrafish embryos.

Hematopoiesis News

High-Dose Chemotherapy and Autologous Hematopoietic Stem-Cell Transplantation in Older, Fit Patients with Primary Diffuse Large B-Cell CNS Lymphoma (MARTA): A Single-Arm, Phase II Trial

[Lancet Haematology] Patients aged 65 years or older with newly diagnosed, untreated primary diffuse large B-cell CNS lymphoma were enrolled if they had an Eastern Cooperative Oncology Group performance status of 0–2 and were fit for high-dose chemotherapy and autologous HSCT.

Hematopoiesis News

3D Amplified Single-Cell RNA and Protein Imaging Identifies Oncogenic Transcript Subtypes in B Cell Acute Lymphoblastic Leukemia

[ACS Nano] The 3D digital rolling circle amplification technique presented could distinguish BCR-ABL1 fusion transcript positive B-cell acute lymphoblastic leukemia cells with or without CD19 protein expression.

Hematopoiesis News

Peroxisome Deficiency Underlies Failures in Hepatic Immune Cell Development and Antigen Presentation in a Severe Zellweger Disease Model

[Cell Reports] Scientists characterized the hepatic immune compartment of a neonatal peroxisome biogenesis disorders mouse model at single-cell resolution to establish the importance and function of peroxisomes in developmental hematopoiesis.

Hematopoiesis News

Phosphatase, Mg2+/Mn2+ Dependent 1B Regulates the Hematopoietic Stem Cells Homeostasis via the Wnt/β-Catenin Signaling

[Haematologica] By using a conditional knockout mouse model in which Ppm1b was specifically depleted in hematopoietic cells, researchers demonstrated that loss of Ppm1b impaired the HSC homeostasis and hematopoietic reconstitution.

Hematopoiesis News

Exonic Knockout and Knockin Gene Editing in Hematopoietic Stem and Progenitor Cells Rescues RAG1 Immunodeficiency

[Science Translational Medicine] Investigators developed gene editing strategies targeting a corrective sequence into the human RAG1 gene by homology-directed repair and validated them by tailored 2D, 3D, and in vivo xenotransplant platforms to assess rescue of expression and function.

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Survival Outcomes of Apalutamide as a Starting Treatment: Impact in Real-World Patients With Metastatic Hormone Sensitive Prostate Cancer (OASIS)

[Prostate Cancer and Prostatic Diseases] Scientists evaluated the impact of upfront therapy for metastatic hormone-sensitive prostate cancer on outcomes in real-world clinical practice in the United States.

A TBX2-Driven Signaling Switch From Androgen Receptor to Glucocorticoid Receptor Confers Therapeutic Resistance in Prostate Cancer

[Oncogene] Using human prostate cancer and CRPC cell line models, scientists demonstrated that TBX2 downregulated androgen receptor and upregulated glucocorticoid receptor through direct transcriptional regulation.

Radiotherapy-Resistant Prostate Cancer Cells Escape Immune Checkpoint Blockade through the Senescence-Related Ataxia Telangiectasia and Rad3-Related Protein

[Cancer Communications] Scientists identified a subset of prostate cancer cells that exhibited resistance to radiotherapy, characterized by a reduced antigen presentation capability, which enhanced their ability to evade immune detection and resist cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) blockade.

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Laurisa Dohm

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