lbeveridge

[Cell Reports] Investigators showed that cilia were present on the apical surface of radial glial cells in human fetal forebrain. Interfering with cilia signaling in human organoids by mutating the INPP5E gene led to the formation of ventral telencephalic cell types instead of cortical progenitors and neurons.

[Signal Transduction and Targeted Therapy] The advent of human 3D organoid systems means it is now possible to allow remarkably detailed observation of stem cell morphogens, maintenance and differentiation resemble primary tissues, enhancing the potential to study both human physiology and developmental stage.

[Frontiers in Oncology] Organoids from the epithelioid sarcoma could be serially cultured and maintained in collagen type 1 gels for more than three passages. Developed orthotopic tumor xenografts were detected in the NSG mice.

[Stem Cell Reports] Scientists showed that the trophoblast cells cells resembled placenta- and naive human PSC-derived trophoblast stem cells, based on their transcriptome as well as their in vitro and in vivo differentiation potential.

[Developmental Cell] Investigators found that the epigenetic de-repression unlocked the expression of pregnancy-specific beta-1 glycoprotein genes that exacerbate human mesenchymal progenitor cells aging and serve as potential aging biomarkers.

[Stem Cell Reports] By analyzing transcriptome data from multiple sources, including bulk and single-cell data, investigators showed that the BMP4 procedure generated bona fide trophoblast (TB) with similarities to both placental villous TB and TB generated from TB stem cells.