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Exosomal miR-129-2-3p Promotes Airway Epithelial Barrier Disruption in PM2.5-Aggravated Asthma

The authors investigated the role of exosomal miR-129-2-3p in regulating airway epithelial cell barrier function, its potential targets, and signaling pathways involved in PM2.5-induced aggravation of asthma. Abstract

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3D Cultivation of Non-Small-Cell Lung Cancer Cell Lines Using Four Different Methods

Four NSCLC cell lines, two adenocarcinomas and two squamous cell carcinomas, were first cultured in traditional 2D settings. Their expected expression profiles concerning TTF-1, CK7, CK5, and p40 status were confirmed...

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Activatable Near-Infrared Fluorescence Probe for Real-Time Imaging of PD-L1 Expression in Tumors

Investigators presented for the first time an activatable near-infrared fluorescence imaging probe for the real-time monitoring of PD-L1 expression in vitro and in vivo. The ability of Q-Atezol to detect PD-L1...

Cell Therapy News

Synergistic Effects of Human Umbilical Cord Mesenchymal Stem Cells/Neural Stem Cells and Epidural Electrical Stimulation on Spinal Cord Injury Rehabilitation

[Scientific Reports] Scientists examined neural stem cell changes via mRNA sequencing in an in vitro Transwell co-culture model. They then explored cell interaction mechanisms using proliferation assays, differentiation assays, and neuron complexity analysis.

Hematopoiesis News

Clonal Dynamics after Allogeneic Hematopoietic Cell Transplantation

[Nature] The authors quantified dynamics of long-term stem cell engraftment, the authors sequenced genomes from 2,824 single-cell-derived hematopoietic colonies of ten donor–recipient pairs taken 9–31 years after HLA-matched sibling HCT3.

Hematopoiesis News

FDA Grants Orphan Drug Designation to AND017 for the Treatment of Sickle Cell Disease

[Pharmacy Times] The FDA granted an orphan drug designation to AND017 for the treatment of sickle cell disease (SCD). The preclinical work that supports the ODD for AND017 in SCD will be presented in future scientific meetings and published in journals, according to experts.

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Survival Outcomes of Apalutamide as a Starting Treatment: Impact in Real-World Patients With Metastatic Hormone Sensitive Prostate Cancer (OASIS)

[Prostate Cancer and Prostatic Diseases] Scientists evaluated the impact of upfront therapy for metastatic hormone-sensitive prostate cancer on outcomes in real-world clinical practice in the United States.

A TBX2-Driven Signaling Switch From Androgen Receptor to Glucocorticoid Receptor Confers Therapeutic Resistance in Prostate Cancer

[Oncogene] Using human prostate cancer and CRPC cell line models, scientists demonstrated that TBX2 downregulated androgen receptor and upregulated glucocorticoid receptor through direct transcriptional regulation.

Radiotherapy-Resistant Prostate Cancer Cells Escape Immune Checkpoint Blockade through the Senescence-Related Ataxia Telangiectasia and Rad3-Related Protein

[Cancer Communications] Scientists identified a subset of prostate cancer cells that exhibited resistance to radiotherapy, characterized by a reduced antigen presentation capability, which enhanced their ability to evade immune detection and resist cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) blockade.

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