Justin.choi

[Life Sciences] Euscaphic acid protected vascular endothelial cells against hypoxia-induced apoptosis via ERK1/2 signaling pathway, and tormentic acid brought its efficacy into full play via PI3K/AKT and ERK1/2 signaling pathways.

[Biogerontology ] The authors summarize how sirtuin 1 and other sirtuins may contribute to endothelial cell function and how presence of diseased conditions may alter their expressions to cause endothelial dysfunction.

[Journal of Molecular Histology] The authors found SNHG1 was upregulated in TNF-α-treated HUVECs. They silenced SNHG1 and found it inhibited vascular endothelial cell proliferation and angiogenesis.

[Hutchison China MediTech Limited] Hutchison China MediTech Limited announced that the FDA has granted two Fast Track Designations for the development of surufatinib, for the treatment of both advanced and progressive pancreatic neuroendocrine tumors (NET) and extra-pancreatic NET in patients who are not amenable for surgery.

[The Lancet] The authors demonstrated endothelial cell involvement across vascular beds of different organs in a series of patients with COVID-19.

[Scientific Reports] Researchers investigated whether S-phase kinase-associated protein-2 plays a role in the regulation of endothelial progenitor cell senescence, which is closely associated with aging-related vasculopathy.