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Justin.choi

Euscaphic Acid and Tormentic Acid Protect Vascular Endothelial Cells against Hypoxia-Induced Apoptosis via PI3K/AKT or ERK 1/2 Signaling Pathway

[Life Sciences] Euscaphic acid protected vascular endothelial cells against hypoxia-induced apoptosis via ERK1/2 signaling pathway, and tormentic acid brought its efficacy into full play via PI3K/AKT and ERK1/2 signaling pathways.

Sirtuins Family as a Target in Endothelial Cell Dysfunction: Implications for Vascular Aging

[Biogerontology ] The authors summarize how sirtuin 1 and other sirtuins may contribute to endothelial cell function and how presence of diseased conditions may alter their expressions to cause endothelial dysfunction.

LncRNA SNHG1 Regulates Vascular Endothelial Cell Proliferation and Angiogenesis via miR-196a

[Journal of Molecular Histology] The authors found SNHG1 was upregulated in TNF-α-treated HUVECs. They silenced SNHG1 and found it inhibited vascular endothelial cell proliferation and angiogenesis.

Chi-Med Announces Surufatinib Granted US FDA Fast Track Designations for the Treatment of Both Pancreatic and Non-Pancreatic Neuroendocrine Tumors

[Hutchison China MediTech Limited] Hutchison China MediTech Limited announced that the FDA has granted two Fast Track Designations for the development of surufatinib, for the treatment of both advanced and progressive pancreatic neuroendocrine tumors (NET) and extra-pancreatic NET in patients who are not amenable for surgery.

Endothelial Cell Infection and Endotheliitis in COVID-19

[The Lancet] The authors demonstrated endothelial cell involvement across vascular beds of different organs in a series of patients with COVID-19.

S-Phase Kinase-Associated Protein-2 Rejuvenates Senescent Endothelial Progenitor Cells and Induces Angiogenesis In Vivo

[Scientific Reports] Researchers investigated whether S-phase kinase-associated protein-2 plays a role in the regulation of endothelial progenitor cell senescence, which is closely associated with aging-related vasculopathy.

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Human Hair Follicle Mesenchymal Stem Cell-Derived Exosomes Attenuate UVB-Induced Photoaging via the miR-125b-5p/TGF-β1/Smad Axis

[Biomaterials Research] The authors revealed that exosomes derived from human hair follicle mesenchymal stem cells effectively enhanced the migration and proliferation of human dermal fibroblasts (HDFs) and upregulated the expressions of TGF-β1, p-Smad2/p-Smad3, collagen type 1, and collagen type 3.

CPSF6-RARγ Interacts with Histone Deacetylase 3 to Promote Myeloid Transformation in RARG-Fusion Acute Myeloid Leukemia

[Nature Communications] Using the most prevalent retinoic acid receptor gamma (RARG) fusion, CPSF6-RARG (CR), as a representative, scientists revealed that the CR fusion, enhanced the expansion of myeloid progenitors, impaired their maturation and synergized with RAS mutations to drive more aggressive myeloid malignancies.

Reduced Circulating Sphingolipids and CERS2 Activity Are Linked to T2D Risk and Impaired Insulin Secretion

[Science Advances] Researchers examined whole-body ceramide synthase 2 (Cers2) knockout and rs267738 knock-in mice. Both models exhibited glucose intolerance and impaired insulin secretion in vivo. Islets isolated from these models also demonstrated reduced β cell function, as shown by decreased insulin secretion ex vivo.