Justin.choi

[Cell Death & Disease] Spry1 knockdown in three BRAFV600-mutant cutaneous melanoma cell lines markedly induced cell cycle arrest and apoptosis, repressed cell proliferation in vitro, and impaired tumor growth in vivo.

[Cancers] Using A375 human malignant melanoma cells with glyoxalase 1 (GLO1) deletion, engineered using CRISPR/Cas9, the authors reported the identification of GLO1 as a novel molecular determinant of invasion and metastasis in malignant melanoma.

[Scientific Reports] Researchers indicated that pre-mRNA processing factor 3 served as a tumor active factor in cutaneous squamous cell carcinomas by targeting the JAK2/STAT3 pathway.

[Scientific Reports] Investigators reported that CD103 regulated the development of psoriasiform dermatitis through the control of the function of dermal conventional dendritic cells. Deficiency in CD103 exacerbated psoriasiform dermatitis, accompanied by excessive epidermal hyperplasia and infiltration of inflammatory leukocytes.

[Cellular and Molecular Life Sciences] The authors summarize the current evidence of functionally important long non-coding RNAs in cutaneous biology and in keratinocyte carcinomas.

[Journal of Leukocyte Biology] Investigators highlight the recent advances in extracellular vesicle-mediated crosstalk between melanoma and immune cells and other important cells of the tumor microenvironment.