Justin.choi

Mammary Cell News

Delineating the Role of Osteoprotegerin as a Marker of Breast Cancer Risk among Women with a BRCA1 Mutation

[Hereditary Cancer in Clinical Practice] Scientists provide a review of the emerging preclinical and epidemiologic evidence implicating the dysregulation of progesterone-mediated receptor activator of nuclear factor κB signaling in the pathogenesis of BRCA1-associated breast cancer.

Pulmonary Cell News

LncRNA PCAT1 Activates SOX2 and Suppresses Radioimmune Responses via Regulating cGAS/STING Signaling in Non-Small Cell Lung Cancer

[Clinical and Translational Medicine] Investigators explored the impacts of prostate cancer-associated ncRNA transcripts 1 (PCAT1) on tumorigenesis and radioimmune responses and the underlying molecular mechanisms in NSCLC.

Pulmonary Cell News

Progenitor Potential of Lung Epithelial Organoid Cells in a Transplantation Model

[Cell Reports] The authors transplanted organoid cells derived from alveolar type II cells enriched by SCA1-negative status or multipotent SCA1-positive progenitor cells into injured mouse lungs.

Pulmonary Cell News

Caspase-9b Drives Cellular Transformation, Lung Inflammation, and Lung Tumorigenesis

[Molecular Cancer Research] A transgenic mouse model expressing human Caspase-9b in the lung pneumocytes developed inflammatory lung lesions, which correlated with enhanced activation of the NF-κB pathway and increased influx of immunosuppressive MDSCs in contrast to wild-type mice.

Pulmonary Cell News

Activity of Adagrasib (MRTX849) in Brain Metastases: Preclinical Models and Clinical Data from Patients with KRASG12C-Mutant Non-small Cell Lung Cancer

[Clinical Cancer Research] A retrospective database query identified patients with KRAS-mutant NSCLC to understand their propensity to develop brain metastases.

Pulmonary Cell News

Cancer Stem-Like Cells Evade CD8+CD103+ Tumor-Resident Memory T (TRM) Lymphocytes by Initiating an Epithelial-to-Mesenchymal Transition Program in a Human Lung Tumor Mode

[Journal For Immunotherapy of Cancer] Researchers supported the rational design of immunotherapeutic strategies targeting cancer stem cells to optimize their responsiveness to local CD8+CD103+ TRM cells for more efficient anticancer treatments.

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Stromal Architecture and Fibroblast Subpopulations with Opposing Effects on Outcomes in Hepatocellular Carcinoma

[Cell Discovery] By combining pathological image analysis with spatial proteomics, scientists revealed two stromal archetypes in HCC with different biological functions and extracellular matrix compositions.

CircTTC13 Promotes Sorafenib Resistance in Hepatocellular Carcinoma through the Inhibition of Ferroptosis by Targeting the miR-513a-5p/SLC7A11 Axis

[Molecular Cancer] Through circRNA sequencing, researchers identified a novel hsa_circ_0000195 that was overexpressed in HCC tissues. This overexpression was linked to higher tumor grade, more advanced tumor stage, decreased ferroptosis, and poorer overall survival.

MELK Prevents Radiofrequency Ablation-Induced Immunogenic Cell Death and Antitumor Immune Response by Stabilizing FABP5 in Hepatocellular Malignancies

[Military Medical Research] Investigators aimed to identify the critical targets for regulating the efficacy of radiofrequency ablation. Nanoparticles with high affinity to tumor cells were applied as a new therapy to interfere with the expression of maternal embryonic leucine zipper kinase (MELK).

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Justin.choi

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