Justin.choi

Mammary Cell News

Diosgenin Derivatives Developed from Pd(ii) Catalysed Dehydrogenative Coupling Exert an Effect on Breast Cancer Cells by Abrogating Their Growth and Facilitating Apoptosis via Regulating...

[Dalton Transactions] Based on the pharmacological importance of diosgenin, the obtained derivatives were exposed to study their effect on breast cancer cells where they significantly reduced the growth of cancer cells and left non-malignant breast epithelial cells unaffected.

Mammary Cell News

Clinically Relevant CHK1 Inhibitors Abrogate Wild-Type and Y537S Mutant ERα Expression and Proliferation in Luminal Primary and Metastatic Breast Cancer Cells

[Journal of Experimental & Clinical Cancer Research] The authors evaluated if kinases could be new targets for the treatment of luminal primary and metastatic breast cancers.

Mammary Cell News

Nrf2 and NF-κB/NLRP3 Inflammasome Pathways Are Involved in Prototheca bovis Infections of Mouse Mammary Gland Tissue and Mammary Epithelial Cells

[Free Radical Biology and Medicine] Investigators characterized how Prototheca bovis induced inflammatory responses in mouse mammary gland tissue and mammary epithelial cells.

Mammary Cell News

Modified Bovine Milk Exosomes for Doxorubicin Delivery to Triple-Negative Breast Cancer Cells

[ACS Applied Bio Materials] Scientists described the use of two chemical modifications, incorporating a neuropilin receptor agonist peptide and a hypoxia-responsive lipid for targeting and release of an encapsulated drug from bovine milk exosomes toTNBC cells.

Mammary Cell News

Dinaciclib Inhibits the Stemness of Two Subtypes of Human Breast Cancer Cells by Targeting the FoxM1 and Hedgehog Signaling Pathway

[Oncology Reports] Investigators aimed to examine the stemness‑inhibitory effects of dinaciclib in MCF‑7 and HCC‑1806 breast cancer cells.

Mammary Cell News

Breast Cancer in the Era of Integrating “Omics” Approaches

[Oncogenesis] The authors investigated the correlation between different “omics” datasets and to define the new important key pathway and upstream regulators in breast cancer.

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Stromal Architecture and Fibroblast Subpopulations with Opposing Effects on Outcomes in Hepatocellular Carcinoma

[Cell Discovery] By combining pathological image analysis with spatial proteomics, scientists revealed two stromal archetypes in HCC with different biological functions and extracellular matrix compositions.

CircTTC13 Promotes Sorafenib Resistance in Hepatocellular Carcinoma through the Inhibition of Ferroptosis by Targeting the miR-513a-5p/SLC7A11 Axis

[Molecular Cancer] Through circRNA sequencing, researchers identified a novel hsa_circ_0000195 that was overexpressed in HCC tissues. This overexpression was linked to higher tumor grade, more advanced tumor stage, decreased ferroptosis, and poorer overall survival.

MELK Prevents Radiofrequency Ablation-Induced Immunogenic Cell Death and Antitumor Immune Response by Stabilizing FABP5 in Hepatocellular Malignancies

[Military Medical Research] Investigators aimed to identify the critical targets for regulating the efficacy of radiofrequency ablation. Nanoparticles with high affinity to tumor cells were applied as a new therapy to interfere with the expression of maternal embryonic leucine zipper kinase (MELK).

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Justin.choi

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