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Justin.choi

Large-Scale Analysis of MicroRNA Expression in Motor Neuron-Like Cells Derived from Human Umbilical Cord Blood Mesenchymal Stem Cells

[Scientific Reports] Human CB-MSCs were isolated and characterized using flow cytometry. Cell differentiation has been induced by combining retinoic acid and sonic hedgehog in a two-step protocol for 14 days.

Human Placental Development and Function

[Seminars in Cell & Developmental Biology] Scientists examine current knowledge of early human placental development, discuss the critical role of the maternal endometrium and of the fetal-maternal dialogue in pregnancy success, and they explore the latest models of trophoblast and endometrial stem cells.

Essent Biologics Launches Human Mesenchymal Stem Cells for Regenerative Medicine, Biopharmaceutical and Cell Therapy Research

[Essent Biologicsâ„¢ (PR NewsWire, Inc.)] Essent Biologicsâ„¢ announced the launch of its human mesenchymal stem cells for regenerative medicine, biopharmaceutical and cell therapy research.

H3K27me3 Conditions Chemotolerance in Triple-Negative Breast Cancer

[Nature Genetics] By monitoring epigenomes, transcriptomes and lineages with single-cell resolution, scientists showed that the repressive histone mark trimethylation of histone H3 at lysine 27 (H3K27me3) regulated cell fate at the onset of chemotherapy.

Progesterone Activates GPR126 to Promote Breast Cancer Development via the Gi Pathway

[Proceedings of the National Academy of Sciences of the United States of America] Scientists identified a membrane receptor for progesterone/17-hydroxyprogesterone and delineated the mechanisms by which GPR126 participated in potential tumor progression in TNBC.

LINC00355 Regulates p27KIP Expression by Binding to MENIN to Induce Proliferation in Late-Stage Relapse Breast Cancer

[npj Breast Cancer] Researchers identified 1127 lncRNAs differentially expressed in late-stage relapse (LSR) breast cancer (BC) via transcriptome sequencing and analysis of 72 early-stage and 24 LSR BC patient tumors.

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ACSS1-Dependent Acetate Utilization Rewires Mitochondrial Metabolism to Support AML and Melanoma Tumor Growth and Metastasis

[Cell Reports] Scientists reported that acetyl-CoA synthetases (ACSS) 1 and 2 were differentially expressed in cancer. ACSS1 knockdown decreased acute myeloid leukemia burden in vivo and inhibited melanoma tumor and metastatic growth.

Sanofi, A*STAR, and the National Skin Centre Partner to Advance Research in Acne Treatment

[A*STAR] Sanofi, the Agency for Science, Technology and Research (A*STAR), and the National Skin Centre Singapore established a Memorandum of Understanding to advance research in acne treatment. This collaboration will encompass a Phase I clinical study in patients with mild acne.

RTI Surgical Announces First Patient Enrolled in Investigational Device Exemption (IDE) for Cortiva® Allograft Dermis in Breast Reconstruction

[RTI Surgical] RTI Surgical announced the enrollment of the first patient in ADMIRE. This IDE study is designed to confirm the safety and effectiveness of Cortiva® Allograft Dermis in implant-based breast reconstruction.