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Justin.choi

Large-Scale Analysis of MicroRNA Expression in Motor Neuron-Like Cells Derived from Human Umbilical Cord Blood Mesenchymal Stem Cells

[Scientific Reports] Human CB-MSCs were isolated and characterized using flow cytometry. Cell differentiation has been induced by combining retinoic acid and sonic hedgehog in a two-step protocol for 14 days.

Human Placental Development and Function

[Seminars in Cell & Developmental Biology] Scientists examine current knowledge of early human placental development, discuss the critical role of the maternal endometrium and of the fetal-maternal dialogue in pregnancy success, and they explore the latest models of trophoblast and endometrial stem cells.

Essent Biologics Launches Human Mesenchymal Stem Cells for Regenerative Medicine, Biopharmaceutical and Cell Therapy Research

[Essent Biologicsâ„¢ (PR NewsWire, Inc.)] Essent Biologicsâ„¢ announced the launch of its human mesenchymal stem cells for regenerative medicine, biopharmaceutical and cell therapy research.

H3K27me3 Conditions Chemotolerance in Triple-Negative Breast Cancer

[Nature Genetics] By monitoring epigenomes, transcriptomes and lineages with single-cell resolution, scientists showed that the repressive histone mark trimethylation of histone H3 at lysine 27 (H3K27me3) regulated cell fate at the onset of chemotherapy.

Progesterone Activates GPR126 to Promote Breast Cancer Development via the Gi Pathway

[Proceedings of the National Academy of Sciences of the United States of America] Scientists identified a membrane receptor for progesterone/17-hydroxyprogesterone and delineated the mechanisms by which GPR126 participated in potential tumor progression in TNBC.

LINC00355 Regulates p27KIP Expression by Binding to MENIN to Induce Proliferation in Late-Stage Relapse Breast Cancer

[npj Breast Cancer] Researchers identified 1127 lncRNAs differentially expressed in late-stage relapse (LSR) breast cancer (BC) via transcriptome sequencing and analysis of 72 early-stage and 24 LSR BC patient tumors.

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STMN1 Regulates the Stemness of Gastric Cancer Cells by Binding to HN1L to Activate the STAT3 Signaling Pathway

[Discover Oncology] STMN1 regulated gastric cancer cell stemness by binding HN1L to activate the HN1L/STAT3/ PD-L1 signaling pathway.

FOSL1 Drives the Malignant Progression of Pancreatic Cancer Cells by Regulating Cell Stemness, Metastasis and Multidrug Efflux System

[Journal of Translational Medicine] FOS like 1 (FOSL1) promote the malignant progression of pancreatic cancer by promoting HMGA1 expression. Targeting FOSL1 and HMGA1 in monotherapy or combination therapy is a promising strategy for the treatment of advanced and metastasis pancreatic cancer.

Super-Enhancer-Hijacking RBBP7 Potentiates Metastasis and Stemness of Breast Cancer via Recruiting NuRD Complex Subunit LSD1

[Journal of Translational Medicine] Researchers uncovered the epigenetic roles of RBBP7 on breast cancer stemness and metastasis.