Jamie Kang

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Comparatively Sonodynamic, Photodynamic and Sonophotodynamic Therapy Activity of Fluorinated Pyridine Substituted Silicon Phthalocyanines on PC3 Prostate Cancer Cell Line

[Cell Reports Medicine] Scientists unveiled a chromosomal instability tolerance mechanism as a therapeutic vulnerability of therapy-refractory lethal prostate cancer.

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Molecular Interplay between NOX1 and Autophagy in Cadmium-Induced Prostate Carcinogenesis

[Free Radical Biology And Medicine] Investigators showed that acute or chronic cadmium exposure facilitated NOX1 assembly by activating its cytosolic regulators p47phox and p67phox in RWPE-1 cells.

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Cardiac Glycoside Neriifolin Exerts Anti-cancer Activity in Prostate Cancer Cells by Attenuating DNA Damage Repair through Endoplasmic Reticulum Stress

[Biochemical Pharmacology] Investigators reported that cardiac glycoside neriifolin suppressed the malignancy of cancer cells via increasing DNA damage and apoptosis through activation of endoplasmic reticulum stress in prostate cancers.

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Synthesis of Hydrocortisone Esters Targeting Androgen and Glucocorticoid Receptors in Prostate Cancer In Vitro

[Journal Of Steroid Biochemistry And Molecular Biology] Scientists introduced the synthesis of novel 17α- and/or 21-ester or carbamate derivatives of hydrocortisone and evaluation of their biological activity towards androgen and glucocorticoid receptors in different prostate cancer cell lines.

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Megakaryocyte-Derived IL-8 Acts as a Paracrine Factor for Prostate Cancer Aggressiveness through CXCR2 Activation and Antagonistic AR Downregulation

[Biomolecules & Therapeutics] The authors investigated the role of paracrine interleukin-8 (IL-8) in the antagonistic expression of IL-8 and androgen receptors, and the contribution of IL-8 to prostate cancer aggressiveness.

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Transcription Factor ELF1 Modulates Cisplatin Sensitivity in Prostate Cancer by Targeting MEIS Homeobox 2

[Chemical Research In Toxicology] Researchers discovered that MEIS homeobox was lowly expressed in prostate cancer tissues by bioinformatics analysis, which had a close connection with the T stage and N stage of the tumor.

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The Vps13-Like Protein BLTP2 Regulates Phosphatidylethanolamine Levels to Maintain Plasma Membrane Fluidity and Breast Cancer Aggressiveness

[Nature Cell Biology] Scientists found that bridge-like lipid transport proteins (BLTPs) facilitated the growth of a triple-negative breast cancer cell line and sustained its aggressiveness in an in vivo model of metastasis, suggesting that maintenance of plasma membrane fluidity by BLTP2 may be critical for tumorigenesis in humans.

Autophagy-Targeted NBR1-P62/SQSTM1 Complexes Promote Breast Cancer Metastasis by Sequestering ITCH

[Nature Cell Biology] Investigators showed that autophagy normally suppresses breast cancer metastasis by enabling the clearance of NBR1–p62/SQSTM1 complexes that instruct p63-mediated pro-metastatic basal differentiation programs.

p95HER2, a Truncated Form of the HER2 Oncoprotein, Drives an Immunosuppressive Program in HER2 Breast Cancer That Limits Trastuzumab Deruxtecan Efficacy

[Nature Cancer] Researchers demonstrated that p95HER2, a truncated form of human epidermal growth factor receptor 2 (HER2), drives immune evasion in HER2-positive female breast cancer, enhancing tumor growth and conferring therapy resistance.

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Jamie Kang

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