Jamie Kang

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CircUBXN7 Suppresses Cell Proliferation and Facilitates Cell Apoptosis in Lipopolysaccharide-Induced Cell Injury by Sponging miR-622 and Regulating the IL6ST/JAK1/STAT3 Axis

[International Journal of Biochemistry & Cell Biology] To elucidate the biological functions and mechanism of circular RNA in actual respiratory distress syndrome, scientists found that circUBXN7 was significantly increased in lipopolysaccharide-induced A549 and Beas-2B cell injury.

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A Small Molecule Inhibitor of the UBE2F-CRL5 Axis Induces Apoptosis and Radiosensitization in Lung Cancer

[Signal Transduction and Targeted Therapy] To develop a small molecule available to selectively target neddylation E2 UBE2F for the treatment of lung cancer, researchers utilized a structure-based virtual screen and chemical optimizations to discover HA-9104.

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Reprogramming of Cancer-Associated Fibroblasts by Apoptotic Cancer Cells Inhibits Lung Metastasis via Notch1-WISP-1 Signaling

[Cellular & Molecular Immunology] Researchers demonstrated that conditioned medium from lung cancer-associated fibroblasts (CAFs) exposed to apoptotic cancer cells suppresses TGF-β1-induced migration and invasion of cancer cells and CAFs.

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LCAT1 Is an Oncogenic LncRNA by Stabilizing the IGF2BP2-CDC6 Axis

[Cell Death & Disease] Investigators discovered LCAT1 physically interacted with and stabilized IGF2BP2, an m6A reader protein, by preventing its degradation via autolysosomes in lung cancer cells.

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NT157 Exerts Antineoplastic Activity by Targeting JNK and AXL Signaling in Lung Cancer Cells

[Scientific Reports] Lung cancer was chosen to explore the NT157 multi-target effects as it was found associated with multiple activated oncogenic pathways relevant to the neoplastic phenotype targets of the drug.

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Regulatory Role of ncRNAs in Pulmonary Epithelial and Endothelial Barriers: Molecular Therapy Clues of Influenza-Induced Acute Lung Injury

[Pharmacological Research] The authors review the roles and regulatory mechanisms of ncRNAs and discuss the effects on pulmonary epithelial and endothelial cell barriers.

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HIV Immune Evasin Nef Enhances Allogeneic CAR T Cell Potency

[Nature] To devise a strategy to protect allogeneic CAR T cells from host immune cells, researchers turned to lymphotropic viruses that have evolved integrated mechanisms for the immune escape of virus-infected lymphocytes.

Shigella Infection Is Facilitated by Interaction of Human Enteric α-Defensin 5 with Colonic Epithelial Receptor P2Y11

[Nature Microbiology] Scientists showed that HD5 induced abundant filopodial extensions in epithelial cells that captured Shigella, a major human enteroinvasive pathogen that was able to exploit these filopodia for invasion, revealing a mechanism for HD5-augmented bacterial invasion.

A New Method for Detecting Mixed Mycobacterium tuberculosis Infection and Reconstructing Constituent Strains Provides Insights into Transmission

[Genome Medicine] Scientists presented MixInfect2, a new tool to accurately detect mixed samples from Mycobacterium tuberculosis short-read whole genome sequence data.

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Jamie Kang

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