Jamie Kang

Muscle Cell News

DN200434 Inhibits Vascular Smooth Muscle Cell Proliferation and Prevents Neointima Formation in Mice after Carotid Artery Ligation

[Endocrinology and Metabolism] Researchers investigated whether DN200434 inhibited proliferation and migration of vascular smooth muscle cells and mitochondrial oxidative phosphorylation, and subsequently suppressed neointima formation in a mouse carotid artery ligation model.

The Role of the Dystrophin Glycoprotein Complex in Muscle Cell Mechanotransduction

[Communications Biology] The authors provide an up-to-date perspective on the dystrophin-glycoprotein complex (DGC). They discuss the relationship between muscle cell mechanics and function, as well as the recent research for a role of the DGC in mechanotransduction and maintaining biomechanical integrity of muscle cells.

Survival Outcomes of Apalutamide as a Starting Treatment: Impact in Real-World Patients With Metastatic Hormone Sensitive Prostate Cancer (OASIS)

[Prostate Cancer and Prostatic Diseases] Scientists evaluated the impact of upfront therapy for metastatic hormone-sensitive prostate cancer on outcomes in real-world clinical practice in the United States.

A TBX2-Driven Signaling Switch From Androgen Receptor to Glucocorticoid Receptor Confers Therapeutic Resistance in Prostate Cancer

[Oncogene] Using human prostate cancer and CRPC cell line models, scientists demonstrated that TBX2 downregulated androgen receptor and upregulated glucocorticoid receptor through direct transcriptional regulation.

Radiotherapy-Resistant Prostate Cancer Cells Escape Immune Checkpoint Blockade through the Senescence-Related Ataxia Telangiectasia and Rad3-Related Protein

[Cancer Communications] Scientists identified a subset of prostate cancer cells that exhibited resistance to radiotherapy, characterized by a reduced antigen presentation capability, which enhanced their ability to evade immune detection and resist cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) blockade.

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Jamie Kang

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