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Jamie Kang
Cancer Stem Cell News
CALML3-AS1 Enhances Malignancies and Stemness of Small Cell Lung Cancer Cells through Interacting with DAXX Protein and Promoting GLUT4-Mediated Aerobic Glycolysis
CALML3 antisense RNA 1 (CALML3-AS1), an oncogene, promoted the malignancy and stemness of small cell lung cancer (SCLC) cells by interacting with death domain-associated protein (DAXX) to enhance GLUT4-mediated aerobic glycolysis,...
Cancer Stem Cell News
Stabilization of SQLE mRNA by WTAP/FTO/IGF2BP3-Dependent Manner in HGSOC: Implications for Metabolism, Stemness, and Progression
[Cell Death & Disease] Squalene epoxidase overexpression resulted in enhanced cancer stem cell-like properties, including increased tumorsphere formation and stemness markers expression.
Cancer Stem Cell News
Aging Limits Stemness and Tumorigenesis by Reprogramming Iron Homeostasis
[Nature] Investigators used physiologically aged autochthonous genetically engineered mouse models and primary cells to demonstrate that ageing suppresses lung cancer initiation and progression by degrading the stemness of the alveolar cell of origin.
Cancer Stem Cell News
Cannabidiol Effects in Stem Cells: A Systematic Review
[Biofactors] In this systematic review, the authors analyzed the effect of cannabidiol on both somatic stem cells and cancer stem cells.
Cancer Stem Cell News
SUO-CTC and CG Oncology Announce the First Annual Non-Muscle Invasive Bladder Cancer (NMIBC) Research Fellowship Award
[CG Oncology, Inc.] The Society of Urologic Oncology Clinical Trials Consortium (SUO-CTC), and CG Oncology, Inc. announced the first annual CG-SUO-CTC NMIBC Research Fellowship designed to support the development of outstanding clinical cancer research investigators who have demonstrated a commitment to improving the understanding and treatment of NMIBC.
Mammary Cell News
Co-Culture System of Breast Cancer and Normal Cells to Investigate Inflammation: Using Doxorubicin Encapsulated in Adipose-Derived Exosomes
[Medical Oncology] A co-culture system of malignant and non-malignant breast cells was used to generate an in vitro model reflecting the in vivo cellular microenvironment, and the effects of this treatment were investigated by examining inflammatory genes.
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Survival Outcomes of Apalutamide as a Starting Treatment: Impact in Real-World Patients With Metastatic Hormone Sensitive Prostate Cancer (OASIS)
[Prostate Cancer and Prostatic Diseases] Scientists evaluated the impact of upfront therapy for metastatic hormone-sensitive prostate cancer on outcomes in real-world clinical practice in the United States.
A TBX2-Driven Signaling Switch From Androgen Receptor to Glucocorticoid Receptor Confers Therapeutic Resistance in Prostate Cancer
[Oncogene] Using human prostate cancer and CRPC cell line models, scientists demonstrated that TBX2 downregulated androgen receptor and upregulated glucocorticoid receptor through direct transcriptional regulation.
Radiotherapy-Resistant Prostate Cancer Cells Escape Immune Checkpoint Blockade through the Senescence-Related Ataxia Telangiectasia and Rad3-Related Protein
[Cancer Communications] Scientists identified a subset of prostate cancer cells that exhibited resistance to radiotherapy, characterized by a reduced antigen presentation capability, which enhanced their ability to evade immune detection and resist cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) blockade.