Jamie Kang

Dermal Cell News

Recurrence of Cutaneous Squamous Cell Carcinoma In Situ with Follicular Involvement

[Journal of The American Academy of Dermatology] Scientists reviewed a follicular involvement in a large series of squamous cell carcinoma in situ to determine the rate of recurrence and 42 demographic, treatment, and histologic factors that may be associated with recurrence.

Dermal Cell News

Exploring the Potential of Selective FKBP51 Inhibitors on Melanoma: An Investigation of Their In Vitro and In Vivo Effects

[Cell Death Discovery] Researchers assessed in vitro and in vivo the efficacy against melanoma of selective small molecules targeting FKBP51, called SAFits.

Dermal Cell News

Telomeres in Skin Aging

[Biogerontology] The authors comprehensively analyze the association between telomeres and aging, along with their impact on skin biological function.

Dermal Cell News

Trump Administration Quashes NIH Scientific Integrity Policy

[Science] The now-rescinded policy, designed to protect government researchers from political pressure, strongly endorsed DEI in science

Hepatic Cell News

Liver TET1 Promotes Metabolic Dysfunction-Associated Steatotic Liver Disease

Investigators explored liver TET1 in metabolic dysfunction-associated steatotic liver disease (MASLD) progression. Depleting TET1 using two different strategies substantially alleviated MASLD progression. [EMBO Molecular Medicine] Full ArticleGraphical Abstract

Hepatic Cell News

Myeloid Cell Path to Malignancy: Insights into Liver Cancer

[Trends In Cancer] The authors discuss the evolutionary dynamics of the immune landscape, particularly that of liver-resident Kupffer cells, TREM2+, and SPP1+ macrophages with an active role during liver disease progression, which eventually fuel hepatocarcinogenesis.

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FGFR2 Abrogation Intercepts Pancreatic Ductal Adenocarcinoma Development

[Cancer Research] Analyzing organoids and murine and human pancreatic specimens, scientists found that the receptor tyrosine kinase FGFR2 was progressively up-regulated in mutant KRAS-driven metaplasia, pre-cancerous lesions and classical PDAC.

Nuclear Galectin-1 Promotes KRAS-Dependent Activation of Pancreatic Cancer Stellate Cells

[Proceedings of The National Academy of Sciences of The United States of America] By identifying a nuclear role for galectin-1 in regulating the transcription of oncogenic genes such as KRAS, scientists uncovered a critical mechanism driving pancreatic stellate cell activation and the secretion of protumorigenic factors.

Clinically Compliant Enrichment of Human Pluripotent Stem Cell-Derived Islets

[Science Translational Medicine] The authors developed a protocol that use density gradient centrifugation to enrich target endocrine cell clusters while reducing the number of undesired, incorrectly differentiated cells.

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Jamie Kang

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