Jamie Kang

Immune Regulation News

Selective Regulation of IFN-γ and IL-4 Co-Producing Unconventional T Cells by Purinergic Signaling

[Journal of Experimental Medicine] Scientists showed that MAIT, γδT, and NKT cells expressed P2RX7 and were sensitive to P2RX7-mediated cell death. Mouse peripheral T-bet+ MAIT1, γδT1, and NKT1 cells, especially in the liver, co-express ARTC2 and P2RX7.

Immune Regulation News

NOTCH1 Drives Sexually Dimorphic Immune Responses in Hepatocellular Carcinoma

[Cancer Discovery] The authors demonstrated that NOTCH1, an understudied oncogene in hepatocellular carcinoma, elicits sexually dimorphic anti-tumor immunity and response to FDA-approved immunotherapies.

Immune Regulation News

Salmonella Cancer Therapy Metabolically Disrupts Tumours at the Collateral Cost of T Cell Immunity

[EMBO Molecular Medicine] Researchers used distal T cell receptor and IFNγ reporter mice and a colorectal cancer model to interrogate T cell activity during bacterial cancer therapy with attenuated Salmonella enterica Typhimurium.

Immune Regulation News

TNFR2 Blockade Promotes Antitumoral Immune Response in PDAC by Targeting Activated Treg and Reducing T Cell Exhaustion

[Journal of Immunotherapy of Cancer] Scientists hypothesized that TNFR2 inhibition using a blocking monoclonal antibody could shift the Treg-effector T cell balance in pancreatic ductal adenocarcinoma, thus enhancing antitumoral responses.

Immune Regulation News

Neurotrophic Factor Neuritin Modulates T Cell Electrical and Metabolic State for the Balance of Tolerance and Immunity

[eLife] Researchers identified a novel immune function of the neurotrophic factor Nrn1 in regulating the T cell metabolic state in a cell context-dependent manner and modulating the outcome of an immune response.

Immune Regulation News

IL-37 Suppresses CNS Autoimmunity by Increasing the Frequency of Treg Cells and Reducing CD4+ T Cell-Derived IL-10 Production

[Journal of Neuroinflammation] Investigators examined the effect of IL-37 in an experimental autoimmune encephalomyelitis model after disease onset to determine if it was protective.

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A PSMA-Targeted Tri-Specific Killer Engager Enhances NK Cell Cytotoxicity Against Prostate Cancer

[Cancer Immunology Research] Scientists reported that the prostate-specific membrane antigen (PSMA) Tri-specific Killer Engager specifically bound to PSMA-expressing cells and significantly enhanced expansion, degranulation, and cytokine production of NK cells derived from healthy donors or prostate cancer patients.

Osteoblast-Derived ECM1 Promotes Anti-Androgen Resistance in Bone Metastatic Prostate Cancer

[Advanced Science] Researchers demonstrated that under enzalutamide treatment, osteoblasts in the bone microenvironment secrete increased levels of extracellular matrix protein 1 (ECM1), which affected surrounding prostate cancer cells, promoting tumor cell proliferation and anti-androgen resistance.

Rapid Modulation of Striatal Cholinergic Interneurons and Dopamine Release by Satellite Astrocytes

[Nature Communications] Scientists discovered that striatal astrocytes occupied a cell type-specific anatomical and functional relationship with cholinergic interneurons (ChIs), through which they rapidly excited ChIs and governed dopamine release via nicotinic acetylcholine receptors on subsecond timescales.

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Jamie Kang

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