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Jamie Kang

Intestinal Mucus Barrier: A Potential Therapeutic Target for IBD

[Autoimmunity Reviews] Scientists highlighted the important role of the mucus layer in inflammatory bowel disease (IBD) and the therapies that target the mucus layer in IBD.

Bowel Cancer Is Rising in Younger People Around the World

[NewScientist] More and more people under 50 have been diagnosed with bowel cancer in different parts of the world over the past few decades.

Imlunestrant with or Without Abemaciclib in Advanced Breast Cancer

[New England Journal of Medicine] In a Phase III, open-label trial, scientists enrolled patients with estrogen-receptor-positive, human epidermal growth factor receptor 2–negative advanced breast cancer that recurred or progressed during or after aromatase inhibitor therapy, administered alone or with a cyclin-dependent kinase 4 and 6 inhibitor.

Injectable Doxorubicin-Loaded Hyaluronic Acid-Based Hydrogel for Locoregional Therapy and Inhibiting Metastasis of Breast Cancer

[Colloids and Surfaces B-Biointerfaces] A doxorubicin-loaded injectable hydrogel based on hyaluronic acid was fabricated for locoregional chemotherapy and inhibiting the metastasis of breast cancer.

Eterna Therapeutics Launches Research to Evaluate its Lead Induced Mesenchymal Stem Cell Therapy Candidate’s (ERNA-101) Ability to Induce and Modulate Antitumor Immunity in Ovarian...

[Eterna Therapeutics] Eterna Therapeutics announced it will investigate the ability of its lead induced pluripotent stem cell-derived mesenchymal stem cells-based cell therapy to induce and modulate antitumor immunity in ovarian cancer and breast cancer models through a sponsored research agreement with The University of Texas MD Anderson Cancer Center.

Scientists Get to the Heart of Blood Formation

[TheScientist] Researchers tweak heart-forming organoids to produce blood cells, in a process that mimics embryonic development.

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Survival Outcomes of Apalutamide as a Starting Treatment: Impact in Real-World Patients With Metastatic Hormone Sensitive Prostate Cancer (OASIS)

[Prostate Cancer and Prostatic Diseases] Scientists evaluated the impact of upfront therapy for metastatic hormone-sensitive prostate cancer on outcomes in real-world clinical practice in the United States.

A TBX2-Driven Signaling Switch From Androgen Receptor to Glucocorticoid Receptor Confers Therapeutic Resistance in Prostate Cancer

[Oncogene] Using human prostate cancer and CRPC cell line models, scientists demonstrated that TBX2 downregulated androgen receptor and upregulated glucocorticoid receptor through direct transcriptional regulation.

Radiotherapy-Resistant Prostate Cancer Cells Escape Immune Checkpoint Blockade through the Senescence-Related Ataxia Telangiectasia and Rad3-Related Protein

[Cancer Communications] Scientists identified a subset of prostate cancer cells that exhibited resistance to radiotherapy, characterized by a reduced antigen presentation capability, which enhanced their ability to evade immune detection and resist cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) blockade.