Ishira

[Blood Cancer Journal] In this retrospective study, investigators included adults with relapsed or refractory diffuse large B-cell lymphoma who received loncastuximab tesirine monotherapy as third or fourth line treatment after progressing on second line or third line chimeric antigen receptor T-cell therapy (CAR-T), respectively.

[Proceedings of The National Academy of Sciences of The United States of America] Scientists reported androgen receptor (AR) antagonists with efficacy in AR-overexpressing models. These molecules bound to the ligand-binding domain of the AR, promote AR localization to the nucleus, yet potently and selectively down-regulated AR-target genes.

[iScience] By genetic and pharmacological disruption of glucagon receptor in mice and zebrafish, scientists reported that the ensuing hyperaminoacidemia promoted pancreatic acinar cell proliferation and cell hypertrophy, which could be mitigated by a low protein diet in mice.