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Mesenchymal Cell News
Human Umbilical Cord Mesenchymal Stem Cells-Derived Exosomes for Treating Traumatic Pancreatitis in Rats
[Stem Cell Research & Therapy] Scientists established a rat model of traumatic pancreatitis and evaluated and compared the therapeutic effects of human umbilical cord (hUC)-MSCs and hucMSC-exosomes.
Mesenchymal Cell News
Standard Toxicity Study of Clinical-Grade Allogeneic Human Bone Marrow-Derived Clonal Mesenchymal Stromal Cells
[Stem Cell Research & Therapy] Investigators determined the probable toxicity effects of local and systemic injections of cryopreserved human bone marrow-derived clonal MSCs during subacute and subchronic periods of time.
Mesenchymal Cell News
Magnetic Exposure Using Samarium Cobalt (SmCO5) Increased Proliferation and Stemness of Human Umbilical Cord Mesenchymal Stem Cells (hUC-MSCs)
[Scientific Reports] Researchers investigated the impact of induced static MF on hUC-MSCs using SmCO5.
Cancer Stem Cell News
Knockdown of the Stem Cell Marker Musashi-1 Inhibits Endometrial Cancer Growth and Sensitizes Cells to Radiation
[Stem Cell Research & Therapy] Musashi-1 knockdown resulted in a strong decrease in endometrial cancer proliferation and a loss of radioresistance, suggesting therapeutic potential.
Newsletters
Suppression of Nuclear GSK3 Signaling Promotes Serine/One-Carbon Metabolism and Confers Metabolic Vulnerability in Lung Cancer Cells
[Science Advances] Scientists uncovered a critical role of glycogen synthase kinase 3 (GSK3) in regulating the expression of serine/one-carbon metabolic enzymes.
Newsletters
MERS-CoV Endoribonuclease and Accessory Proteins Jointly Evade Host Innate Immunity during Infection of Lung and Nasal Epithelial Cells
[Proceedings of the National Academy of Sciences of the United States of America] Researchers investigated the antagonist effects of the conserved coronavirus endoribonuclease, in combination with NS4a or NS4b.
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CHIKV mRNA Vaccines Encoding Conserved Structural/Envelope Proteins Confer Broad Cross-Lineage Protection against Infection
[Signal Transduction and Targeted Therapy] Scientists designed chikungunya virus (CHIKV) mRNA vaccines containing full-length structural proteins or part of structural proteins based on conserved sequences from 769 viral strains encompassing four lineages.
T Cell-Derived IFN-γ Suppresses T Follicular Helper Cell Differentiation and Antibody Responses
[EMBO Journal] Researchers showed that T-bet+ cells induced by lymphocytic choriomeningitis virus infection encompassed a TH1 cell subset expressing granzyme B and a Tcf-1+ cell subset that retained the potential for T follicular helper (TFH) differentiation without expressing mature TFH markers.
Distinct Type 1 Immune Networks Underlie the Severity of Restrictive Lung Disease after COVID-19
[Nature Immunology] Scientists analyzed hundreds of cellular and molecular features in the context of discrete pulmonary phenotypes to define the systemic immune landscape of post-COVID lung disease.
