Emily Salmini

[Hepatology] Short-term starvation was found to attenuate tumor progression by inducing tumor-associated macrophages to switch to an antitumoral phenotype, and stimulating subsequent anti-tumor immunity of CD8+ T cells as demonstrated in three HCC mouse models.

[Hepatology] The authors identified a novel genetic variant in a familial case of metabolic dysfunction-associated steatohepatitis and performed deep variant functional analysis to assess molecular mechanisms of dysfunction and altered cellular signaling.

[Science Advances] Scientists examined hepatic fat oxidation and ketogenesis as a contributor to de novo lipogenesis (DNL) and to polyunsaturated fatty acid elongation, a lipogenic metabolic pathway distinct from DNL and with no known prior connection to ketone body metabolism.

[Journal of Experimental & Clinical Cancer Research] A heat shock transcriptional factor 4 (HSF4) knockout colorectal cancer cell model was cultured in different ECM stiffness to evaluate the effects of HSF4 on cell proliferation, migration, and invasion in vitro and in vivo.

[Nature Communications] Researchers developed highly optimized small molecule-inducible synthetic erythropoietin (EPO) receptors (synEPORs) using design-build-test cycles and genome editing. They integrated synEPOR at the endogenous EPOR locus in O-negative induced pluripotent stem cells.

[Journal of Cell Biology] Scientists identifed a stem cell–specific role for ceramide synthase 4 (CerS4) in orchestrating fate decisions in skin epidermis. CerS4 prevented the proper development of the adult hair follicle bulge stem cell compartment due to altered differentiation trajectories.