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Danielle Corrigan

Nanoparticle-Induced Chemoresistance: The Emerging Modulatory Effects of Engineered Nanomaterials on Human Intestinal Cancer Cell Redox Metabolic Adaptation

[Nanoscale] Investigators screened several representative food-borne comparator engineered nanomaterials and reported that human colon cancer cells could insidiously exploit ZnO nanoparticle-induced adaptive response to acquire resistance against several chemotherapeutic drugs.

NudCD1 as a Prognostic Marker in Colorectal Cancer and Its Role in the Upregulation of Cellular Spindle Assembly Checkpoint Genes and LIS1 Pathways

[BMC Cancer] Scientists investigated the role of NudCD1 in spindle assembly checkpoint regulation and in the prognosis of colorectal cancer.

Repurposing Metformin as a Potential Treatment for Inflammatory Bowel Disease: Evidence from Cell to the Clinic

[International Immunopharmacology] Scientists discuss the beneficial effects of metformin on IBD using the results of in vitro, in vivo, and clinical studies.

Transcriptional Switch of Hepatocytes Initiates Macrophage Recruitment and T-Cell Suppression in Endotoxemia

[Journal of Hepatology] The spatial and temporal changes in hepatocytes and non-parenchymal cell types were validated by multiplex immunofluorescence staining, bulk transcriptomic sequencing, or flow cytometry.

TIPE1 Promotes Liver Regeneration by Enhancing Ros-FoxO1 Axis Mediated Autophagy

[FEBS Journal] Hepatic Tipe1 deficiency decreased the level of reactive oxygen species in hepatocytes, which led to the inhibition of FoxO1 acetylation and LC3I to LC3II conversion, and p62 accumulation.

Knockdown of Hepatocyte Perilipin-3 Mitigates Hepatic Steatosis and Steatohepatitis Caused by Hepatocyte CGI-58 Deletion in Mice

[Journal of Molecular Biology] Scientists test whether the deletion of a major lipid droplet protein alleviates fatty liver pathogenesis caused by alpha/beta hydrolase domain containing 5 deficiency in hepatocytes.

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Inhibition of Ceramide Synthesis Improves the Outcome of Ischemia/Reperfusion Injury in Cardiomyocytes Derived from Human Induced Pluripotent Stem Cell

[Stem Cell Research & Therapy] Serum- and glucose-free media was used to expose hiPSC-derived cardiomyocytes to hypoxia for 6 hours, followed by reoxygenation for 16 hours.

RFX3 Is Essential for the Generation of Functional Human Pancreatic Islets from Stem Cells

[Diabetologia] Scientists generated regulatory factor X 3 (RFX3) knockout iPSC lines using CRISPR/Cas9 and differentiated them into pancreatic islet organoids.