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MicroRNA 211–5p Inhibits Cancer Cell Proliferation and Migration in Pancreatic Cancer by Targeting BMP2

[Aging] Scientists discovered that miR-211-5p was a significantly downregulated miRNA in pancreatic cancer tissues compared to adjacent non-tumour tissues.

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RFX6 Maintains Gene Expression and Function of Adult Human Islet α Cells

[Diabetes] Investigators developed a method for selective genetic targeting of human α cells and assessed RFX6-dependent α cell function.

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The NERP-4–SNAT2 Axis Regulates Pancreatic β Cell Maintenance and Function

[Nature Communications] The authors demonstrated a novel autocrine mechanism of β cell maintenance and function that was mediated by the peptide–amino acid transporter axis.

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Baricitinib and β Cell Function in Patients with New-Onset Type 1 Diabetes

[New England Journal Of Medicine] In this Phase II, double-blind, randomized, placebo-controlled trial, scientists assigned patients with type 1 diabetes diagnosed during the previous 100 days to receive baricitinib or matched placebo orally for 48 weeks.

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Protein Kinase D1 — a Targetable Mediator of Pancreatic Cancer Development

[Biochimica Et Biophysica Acta-Molecular Cell Research] The authors detail pancreatic expression of protein kinase D enzymes in normal individuals and pancreatitis and PDAC patients, as well as in mouse and rat animal models for these diseases.

Cell Therapy News

Lipid Nanoparticles Efficiently Deliver a Trimeric Spike-Encoded DNA Vaccine to Robustly Induce Anti-SARS-CoV-2 Immunity Superior to the mRNA Vaccine in Syrian Hamsters

[Molecular Therapy-Methods & Clinical Development] Investigators reported that plasmid encoding a trimeric spike protein with lipid nanoparticle delivery (pTS/LNP), similar to those in Moderna's COVID-19 vaccine, induced more effective humoral responses than naked pTS or pTS delivered via electroporation.

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A PSMA-Targeted Tri-Specific Killer Engager Enhances NK Cell Cytotoxicity Against Prostate Cancer

[Cancer Immunology Research] Scientists reported that the prostate-specific membrane antigen (PSMA) Tri-specific Killer Engager specifically bound to PSMA-expressing cells and significantly enhanced expansion, degranulation, and cytokine production of NK cells derived from healthy donors or prostate cancer patients.

Osteoblast-Derived ECM1 Promotes Anti-Androgen Resistance in Bone Metastatic Prostate Cancer

[Advanced Science] Researchers demonstrated that under enzalutamide treatment, osteoblasts in the bone microenvironment secrete increased levels of extracellular matrix protein 1 (ECM1), which affected surrounding prostate cancer cells, promoting tumor cell proliferation and anti-androgen resistance.

Rapid Modulation of Striatal Cholinergic Interneurons and Dopamine Release by Satellite Astrocytes

[Nature Communications] Scientists discovered that striatal astrocytes occupied a cell type-specific anatomical and functional relationship with cholinergic interneurons (ChIs), through which they rapidly excited ChIs and governed dopamine release via nicotinic acetylcholine receptors on subsecond timescales.

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