Bob

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MicroRNA 211–5p Inhibits Cancer Cell Proliferation and Migration in Pancreatic Cancer by Targeting BMP2

[Aging] Scientists discovered that miR-211-5p was a significantly downregulated miRNA in pancreatic cancer tissues compared to adjacent non-tumour tissues.

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RFX6 Maintains Gene Expression and Function of Adult Human Islet α Cells

[Diabetes] Investigators developed a method for selective genetic targeting of human α cells and assessed RFX6-dependent α cell function.

Newsletters

The NERP-4–SNAT2 Axis Regulates Pancreatic β Cell Maintenance and Function

[Nature Communications] The authors demonstrated a novel autocrine mechanism of β cell maintenance and function that was mediated by the peptide–amino acid transporter axis.

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Baricitinib and β Cell Function in Patients with New-Onset Type 1 Diabetes

[New England Journal Of Medicine] In this Phase II, double-blind, randomized, placebo-controlled trial, scientists assigned patients with type 1 diabetes diagnosed during the previous 100 days to receive baricitinib or matched placebo orally for 48 weeks.

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Protein Kinase D1 — a Targetable Mediator of Pancreatic Cancer Development

[Biochimica Et Biophysica Acta-Molecular Cell Research] The authors detail pancreatic expression of protein kinase D enzymes in normal individuals and pancreatitis and PDAC patients, as well as in mouse and rat animal models for these diseases.

Cell Therapy News

Lipid Nanoparticles Efficiently Deliver a Trimeric Spike-Encoded DNA Vaccine to Robustly Induce Anti-SARS-CoV-2 Immunity Superior to the mRNA Vaccine in Syrian Hamsters

[Molecular Therapy-Methods & Clinical Development] Investigators reported that plasmid encoding a trimeric spike protein with lipid nanoparticle delivery (pTS/LNP), similar to those in Moderna's COVID-19 vaccine, induced more effective humoral responses than naked pTS or pTS delivered via electroporation.

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Survival Outcomes of Apalutamide as a Starting Treatment: Impact in Real-World Patients With Metastatic Hormone Sensitive Prostate Cancer (OASIS)

[Prostate Cancer and Prostatic Diseases] Scientists evaluated the impact of upfront therapy for metastatic hormone-sensitive prostate cancer on outcomes in real-world clinical practice in the United States.

A TBX2-Driven Signaling Switch From Androgen Receptor to Glucocorticoid Receptor Confers Therapeutic Resistance in Prostate Cancer

[Oncogene] Using human prostate cancer and CRPC cell line models, scientists demonstrated that TBX2 downregulated androgen receptor and upregulated glucocorticoid receptor through direct transcriptional regulation.

Radiotherapy-Resistant Prostate Cancer Cells Escape Immune Checkpoint Blockade through the Senescence-Related Ataxia Telangiectasia and Rad3-Related Protein

[Cancer Communications] Scientists identified a subset of prostate cancer cells that exhibited resistance to radiotherapy, characterized by a reduced antigen presentation capability, which enhanced their ability to evade immune detection and resist cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) blockade.

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