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[Journal of Neuro-Oncology] The authors investigated the molecular mechanism that induce stem cell features in spinal ependymoma (SE). They found that RFX2 activates PAF1 transcription, which promoted tumor stemness of SE cells and led to the malignant progression of SE.

[Trends In Pharmacological Sciences] Scientists provide an overview of the unique signaling and metabolic pathways of CSCs, summarize existing CSC biomarkers and CSC-targeted therapies, and discuss strategies to further differentiate CSCs from non-stem cancer cells.

[Cell Regeneration] The authors provide a concise overview that highlights the diverse roles of the bone morphogenetic protein (BMP) signaling in various types of cancers.

[NPJ Precision Oncology] Investigators comprehensively unraveled the intra-patient response heterogeneity and intrinsic aggressive nature of PDAC on bulk and single-organoid resolution.

[Acta Pharmacologica Sinica] The authors showed that SMAD4 status almost determined the orientation of transforming growth factor β1 (TGF-β1)-induced epithelial-mesenchymal transition via the SMAD4-dependent canonical pathway in PDAC, which altered ferroptosis vulnerability.

[Advanced Science] Researchers highlighted the important roles of basic helix-loop-helix transcription factor 40 (BHLHE40)-mediated lipid peroxidation in inducing ferroptosis in pancreatic cancer (PCa) cells and provided a novel mechanism underlying sterol regulatory element-binding factor 1 (SREBF1) overexpression in PCa.