Bob

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Inner Ear Organoids: Recent Progress and Potential Applications

[Fundamental Research] To better understand the origin and application value of organoids, the authors reviewe the developmental history and advancement of inner ear organoid research.

Cancer Stem Cell News

Boric Acid Alters the Expression of DNA Double Break Repair Genes in MCF-7-Derived Breast Cancer Stem Cells

[Biological Trace Element Research] The authors investigated the effects of boric acid on the expression of DNA double-strand break repair genes in breast CSCs, which has not been studied in the literature before.

Cancer Stem Cell News

Novel lncRNA Gm33149 Modulates Metastatic Heterogeneity in Melanoma by Regulating the miR-5623-3p/Wnt Axis via Exosomal Transfer

[Cancer Gene Therapy] Scientists investigated the role and mechanism of long non-coding RNAs in regulating the interaction between melanoma CSCs and non-CSCs during the metastatic colonization process.

Cancer Stem Cell News

SIRT6 Promotes Metastasis and Relapse in HER2-Positive Breast Cancer

[Scientific Reports] Scientists investigated the impact of SIRT6-overexpression in Delta16HER2 mice, which were a bona fide model of HER2-positive breast cancer.

Cancer Stem Cell News

Visualizing Cancer-Originating Acetate Uptake through MCT1 in Reactive Astrocytes in the Glioblastoma Tumor Microenvironment

[Neuro-Oncology] Researchers explored acetate from glioblastoma cells, which triggered reactive astrogliosis in neighboring astrocytes by upregulating MAO-B and MCT1 expression.

Cancer Stem Cell News

Fibroblast-Derived Lysyl Oxidase Increases Oxidative Phosphorylation and Stemness in Cholangiocarcinoma

[Gastroenterology] demonstrated how lysyl oxidase (LOX), a known factor in collagen crosslinking, contributes to the development and progression of cholangiocarcinoma

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Survival Outcomes of Apalutamide as a Starting Treatment: Impact in Real-World Patients With Metastatic Hormone Sensitive Prostate Cancer (OASIS)

[Prostate Cancer and Prostatic Diseases] Scientists evaluated the impact of upfront therapy for metastatic hormone-sensitive prostate cancer on outcomes in real-world clinical practice in the United States.

A TBX2-Driven Signaling Switch From Androgen Receptor to Glucocorticoid Receptor Confers Therapeutic Resistance in Prostate Cancer

[Oncogene] Using human prostate cancer and CRPC cell line models, scientists demonstrated that TBX2 downregulated androgen receptor and upregulated glucocorticoid receptor through direct transcriptional regulation.

Radiotherapy-Resistant Prostate Cancer Cells Escape Immune Checkpoint Blockade through the Senescence-Related Ataxia Telangiectasia and Rad3-Related Protein

[Cancer Communications] Scientists identified a subset of prostate cancer cells that exhibited resistance to radiotherapy, characterized by a reduced antigen presentation capability, which enhanced their ability to evade immune detection and resist cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) blockade.

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