Bob

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Endometrial Cancer PDX-Derived Organoids (PDXOs) and PDXs with FGFR2c Isoform Expression Are Sensitive to FGFR Inhibition

[npj Precision Oncology] Researchers reported the establishment of 16 endometrial cancer (EC) PDXOs with or without FGFR2c expression. In vitro treatment of five EC PDXOs with BGJ398 showed significant cell death in three models with FGFR2c expression.

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Single-Cell Transcriptome Profiling of Primary Tumors and Paired Organoids of Pancreatobiliary Cancer

[Cancer Letters] The authors conducted scRNA-seq for paired primary tumors and organoids from one cholangiocarcinoma and two pancreatic ductal adenocarcinoma patients.

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Proteome Signatures of Joint Toxicity to Arsenic (as) and Lead (Pb) in Human Brain Organoids with Optic Vesicles

[Environmental Research] Investigators utilized brain organoids with optic vesicles to systematically analyze the neurotoxicity of arsenic and lead.

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Pathological Deficit of Cystatin B Impairs Synaptic Plasticity in EPM1 Human Cerebral Organoids

[Molecular Neurobiology] Scientists investigated the involvement of cystatin B in synaptic plasticity, using synaptosomes from human cerebral organoids as well as from rodents’ brain.

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3D Hepatic Organoid Production from Human Pluripotent Stem Cells

[Differentiation] Researchers described the stepwise and fully 3D production of hepatic organoids from hPSCs. They optimized every differentiation step by screening for optimal concentrations and timing of differentiation signals in each differentiation step.

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Bioprinting Using Organ Building Blocks: Spheroids, Organoids, and Assembloids

[Tissue Engineering Part A] Investigators discuss the expanding range of organ building blocks (OBB), presents the rapidly evolving collection of bioprinting and bioassembly methods using these OBB, and outlines the advantages, challenges, and future perspectives of employing OBB in organ printing.

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A PSMA-Targeted Tri-Specific Killer Engager Enhances NK Cell Cytotoxicity Against Prostate Cancer

[Cancer Immunology Research] Scientists reported that the prostate-specific membrane antigen (PSMA) Tri-specific Killer Engager specifically bound to PSMA-expressing cells and significantly enhanced expansion, degranulation, and cytokine production of NK cells derived from healthy donors or prostate cancer patients.

Osteoblast-Derived ECM1 Promotes Anti-Androgen Resistance in Bone Metastatic Prostate Cancer

[Advanced Science] Researchers demonstrated that under enzalutamide treatment, osteoblasts in the bone microenvironment secrete increased levels of extracellular matrix protein 1 (ECM1), which affected surrounding prostate cancer cells, promoting tumor cell proliferation and anti-androgen resistance.

Rapid Modulation of Striatal Cholinergic Interneurons and Dopamine Release by Satellite Astrocytes

[Nature Communications] Scientists discovered that striatal astrocytes occupied a cell type-specific anatomical and functional relationship with cholinergic interneurons (ChIs), through which they rapidly excited ChIs and governed dopamine release via nicotinic acetylcholine receptors on subsecond timescales.

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