Britya Ghosh

[Journal of Immunology Research] Hypoxia induced by using CoCl2 application and 14-3-3β protein knockdown by specific small interfering RNA transfection were performed in GSCs both in vitro and in vivo to observe their role in glioma progression and metastasis occurrence by using western blot analysis and MTT assay.

[Trends in Cell Biology] Investigators suggested that focusing on the early interaction between stem cells harbouring mutations in cancer-driver genes and the surrounding tissue cells, which might also carry genetic mutations, might hold the key to this understanding.

[Foghorn Therapeutics, Inc. (BioSpace, Inc.)] Foghorn Therapeutics Inc. announced the FDA has placed the Phase I dose escalation study of FHD-286 in relapsed and/or refractory acute myelogenous leukemia and myelodysplastic syndrome on a partial clinical hold.

[Nature Communications] Researchers identified oxidative phosphorylation as a critical pathway for leukemia cell survival and demonstrate a direct relationship between NOTCH1, elevated OxPhos gene expression, and acquired chemoresistance in pre-leukemic and leukemic models.

[Leukemia] To investigate the physiological significance of p27 tyrosine phosphorylation, scientists generated a knock-in mouse model where Y88 was replaced by phenylalanine.

[Blood Advances] The authors identified LIN28B known for its role in promoting fetal-like self-renewal, as an insulator against the establishment of a megakaryocyte biased hematopoietic stem cell pool.