Britya Ghosh

Cancer Stem Cell News

Disruption of β-Catenin-Mediated Negative Feedback Reinforces cAMP-Induced Neuronal Differentiation in Glioma Stem Cells

[Cell Death & Disease] Scientists demonstrated that cAMP triggered neuronal differentiation and compromised the self-renewal capacity in glioma stem cells.

Cancer Stem Cell News

GSK3β Palmitoylation Mediated by ZDHHC4 Promotes Tumorigenicity of Glioblastoma Stem Cells in Temozolomide-Resistant Glioblastoma through the EZH2–STAT3 Axis

[Oncogenesis] Researchers found that GSK3β was noted as a substrate for ZDHHC4-mediated palmitoylation at the Cys14 residue, which enhanced glioblastoma temozolomide resistance and glioblastoma stem cell self-renewal.

Cancer Stem Cell News

ΔNp63α Mediates Sulforaphane Suppressed Colorectal Cancer Stem Cell Properties through Transcriptional Regulation of Nanog/Oct4/Sox2

[Journal of Nutritional Biochemistry] Scientists showed that ΔNp63α expression was enhanced in sphere-forming colorectal cancer cells.

Cancer Stem Cell News

Identification of Two Cancer Stem Cell-Like Populations in Triple-Negative Breast Cancer Xenografts

[Disease Models & Mechanisms] The multiple-microtissue transcriptome analysis revealed three cancer cell-type clusters in the primary tumor and axillary lymph node metastasis, two of which were CSC-like clusters.

Cancer Stem Cell News

GM-CSF-miRNA-Jak2/Stat3 Signaling Mediates Chemotherapy-Induced Cancer Cell Stemness in Gastric Cancer

[Frontiers in Pharmacology] Researchers treated two human gastric cancer cell lines SGC7901 and BGC823 with 5-Fluorouracil or Cisplatin in vitro.

Cancer Stem Cell News

Recombinant Expression a Novel Fibronectin—Collage Fusion Peptide Modulating Stem Cell Stemness via Integrin β3

[Applied Microbiology and Biotechnology] A novel recombinant protein fibronectin-collagen peptide was designed to modulate the function of extracellular matrix expressed by Picha. pastoris strain X33.

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Survival Outcomes of Apalutamide as a Starting Treatment: Impact in Real-World Patients With Metastatic Hormone Sensitive Prostate Cancer (OASIS)

[Prostate Cancer and Prostatic Diseases] Scientists evaluated the impact of upfront therapy for metastatic hormone-sensitive prostate cancer on outcomes in real-world clinical practice in the United States.

A TBX2-Driven Signaling Switch From Androgen Receptor to Glucocorticoid Receptor Confers Therapeutic Resistance in Prostate Cancer

[Oncogene] Using human prostate cancer and CRPC cell line models, scientists demonstrated that TBX2 downregulated androgen receptor and upregulated glucocorticoid receptor through direct transcriptional regulation.

Radiotherapy-Resistant Prostate Cancer Cells Escape Immune Checkpoint Blockade through the Senescence-Related Ataxia Telangiectasia and Rad3-Related Protein

[Cancer Communications] Scientists identified a subset of prostate cancer cells that exhibited resistance to radiotherapy, characterized by a reduced antigen presentation capability, which enhanced their ability to evade immune detection and resist cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) blockade.

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Britya Ghosh

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