Britya Ghosh

Cancer Stem Cell News

Disruption of β-Catenin-Mediated Negative Feedback Reinforces cAMP-Induced Neuronal Differentiation in Glioma Stem Cells

[Cell Death & Disease] Scientists demonstrated that cAMP triggered neuronal differentiation and compromised the self-renewal capacity in glioma stem cells.

Cancer Stem Cell News

GSK3β Palmitoylation Mediated by ZDHHC4 Promotes Tumorigenicity of Glioblastoma Stem Cells in Temozolomide-Resistant Glioblastoma through the EZH2–STAT3 Axis

[Oncogenesis] Researchers found that GSK3β was noted as a substrate for ZDHHC4-mediated palmitoylation at the Cys14 residue, which enhanced glioblastoma temozolomide resistance and glioblastoma stem cell self-renewal.

Cancer Stem Cell News

ΔNp63α Mediates Sulforaphane Suppressed Colorectal Cancer Stem Cell Properties through Transcriptional Regulation of Nanog/Oct4/Sox2

[Journal of Nutritional Biochemistry] Scientists showed that ΔNp63α expression was enhanced in sphere-forming colorectal cancer cells.

Cancer Stem Cell News

Identification of Two Cancer Stem Cell-Like Populations in Triple-Negative Breast Cancer Xenografts

[Disease Models & Mechanisms] The multiple-microtissue transcriptome analysis revealed three cancer cell-type clusters in the primary tumor and axillary lymph node metastasis, two of which were CSC-like clusters.

Cancer Stem Cell News

GM-CSF-miRNA-Jak2/Stat3 Signaling Mediates Chemotherapy-Induced Cancer Cell Stemness in Gastric Cancer

[Frontiers in Pharmacology] Researchers treated two human gastric cancer cell lines SGC7901 and BGC823 with 5-Fluorouracil or Cisplatin in vitro.

Cancer Stem Cell News

Recombinant Expression a Novel Fibronectin—Collage Fusion Peptide Modulating Stem Cell Stemness via Integrin β3

[Applied Microbiology and Biotechnology] A novel recombinant protein fibronectin-collagen peptide was designed to modulate the function of extracellular matrix expressed by Picha. pastoris strain X33.

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Preclinical Evaluation of Zirconium-89 Labeled Anti-Trop2 Antibody-Drug Conjugate (Trodelvy) for Imaging in Gastric Cancer and Triple-Negative Breast Cancer

[European Journal of Nuclear Medicine and Molecular Imaging] Leveraging the enhanced specificity of antibody-drug conjugate, researchers conducted the first immunoPET imaging study of Trop2 expression in gastric cancer and TNBC models using 89Zr-labeled Trodelvy.

S100A8/A9 Innate Immune Signaling as a Distinct Mechanism Driving Progression of Smoking-Related Breast Cancers

[Oncogene] Investigators showed that S100A8/A9 innate immune signaling was a molecular mechanism that identified smoking-related breast cancers and underlied their enhanced malignancy.

The PI4K2A Gene Positively Regulates Lipid Synthesis in Bovine Mammary Epithelial Cells and Attenuates the Inhibitory Effect of t10, c12-CLA on Lipid Synthesis

[Scientific Reports] Scientists used primary bovine mammary epithelial cells (BMECs) as a model and utilized overexpression and knockdown techniques for the PI4K2A gene to investigate the specific mechanisms by which it regulated lipid metabolism in BMECs.

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Britya Ghosh

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