[Kazinform International News Agency] Under the patronage and in the presence Zaki Nusseibeh, Cultural Adviser to the UAE President and Chancellor of the United Arab Emirates University (UAEU), UAEU inaugurated the Stem Cells Research Centre, the first of its kind in the academic world in the UAE.

[Cell Death Discovery] Researchers showed that silencing of staphylococcal nuclease domain-containing protein 1 (SND1) augmented the sensitivity of NSCLC cells to different chemotherapeutic drugs.

[Journal of Drug Targeting] The authors discuss the regulatory role of microRNAs in fine-tuning endoplasmic Reticulum (ER) stress pathways in NSCLC and highlight various promising strategies to overcome chemoresistance by targeting ER stress pathways, offering new therapeutic opportunities.

[Cancer Cell International] Multiple public datasets and an in-house cohort were utilized to assess the clinical relevance of dishevelled-associated activator of morphogenesis1 (DAAM1) in pancreatic cancer.

[Science Translational Medicine] The authors found that advanced glycosylation end product–specific receptor (AGER) contributed to MRTX1133 resistance in PDAC through modulation of macropinocytosis and glutathione synthesis using patient-derived xenografts and orthotopic and genetically engineered mouse models.

[Cellular and Molecular Life Sciences] The protein expression profiles of pancreatic tissues from normal and obese T2DM mice were analyzed, revealing that nuclear factor of activated T cells 5 (NFAT5) and ferroptosis were potential mediators and mechanisms of β-cell damage in obese T2DM mice.

[Arteriosclerosis Thrombosis and Vascular Biology] The authors performed a high-resolution imaging and time-lapse imaging analysis of the behavior of endothelial cells in Tg(kdrl:ras-mCherry::fli1a:nGFP) zebra fish embryos upon high glucose treatment.

[Arteriosclerosis Thrombosis and Vascular Biology] Scientists inhibited in vivo function of XOR either by endothelial cell (EC)–specific disruption of the Xdh gene or by systemic administration of an XOR inhibitor febuxostat in Marfan syndrome mice harboring the Fbn1 missense mutation p.(Cys1041Gly).

[Molecular Medicine] Investigators found that tegaserod maleate, an FDA-approved agent, inhibited proliferation, colony formation, migration as well as invasion, caused the arrest of the cell cycle, and promoted apoptosis of prostate cancer cells in vitro.

[Nature Communications] Scientists identified that a voltage-dependent anion channel 1 (VDAC1) binding protein V-set and transmembrane domain containing 2 like (VSTM2L) was positively associated with prostate cancer progression.

[Cellular and Molecular Life Sciences] Researchers identified a synergistic combination of orally available, safe-in-man pleconaril, AG7404, and mindeudesivir, that at non-toxic concentrations effectively inhibited enterovirus replication in human cell and organoid cultures.

[Clinical Cancer Research] Scientists derived nine patient-derived organoid and patient-derived xenograft models from colorectal signet ring cell carcinoma patients. Detailed histopathological characterization confirmed the fidelity of these models to the original tumors.