[Molecular Oncology] The authors adopted a cancer gene therapy approach to induce -cell-mediated killing of the tumor through increased activation of the immune system.

[Stem Cell Reports] The authors performed spatial transcriptomics on the tongue, cheeks, and palate of the adult mouse to understand the cues that maintain the oral mucosal sites.

[American Journal of Respiratory Cell and Molecular Biology] Investigators described a method for vessel infiltration of human lung organoid (hLO) in which they determined differences of these hLOs with standard avascular hLOs.

[Proceedings of The National Academy of Sciences of The United States of America] Researchers presented a technique, lamination-based organoid spatially resolved transcriptomics, for organoid-spatially resolved transcriptomics based on organoid lamination.

[Journal of Nanobiotechnology] Investigators provide an overview of the fundamental biological principles of organoids and organoid-derived extracellular vesicles, and discuss their current applications in disease treatment.

[Journal of Translational Medicine] The authors explore the application of organoid technology for more precise tumor simulations and its specific contributions to cancer research advancements.

[Journal of Clinical Investigation] Scientists modeled interactions with tumor-mesenchymal stromal cells co-cultures and used an integrated transcriptome-proteome-network-analyses workflow to identify a comprehensive catalog of contact-induced changes.

[Journal of Molecular Medicine] Investigators explored the antitumor action of the combination of sphingosine kinase-1 (SPHK) inhibitors with 2'-nitroflavone. In vitro assays showed that the combination induced a synergistic antiproliferative effect in LM3 cells.

[Med] In this study, researchers performed bioinformatics analysis in a multi-omics TNBC database and identified that a metabolic enzyme, dihydrodiol dehydrogenase (DHDH), might promote the phenotype of “cold tumor” in TNBC.

[Nature Genetics] The authors demonstrated that early tumor onset in a Brca1 heterozygous background could not be fully explained by the conventional "two-hit" hypothesis, suggesting the existence of inherent tumor-promoting alterations in the Brca1 heterozygous state.

[Science Signaling] Researchers found that breast cancer cells forced to perform glycolysis acquired a vulnerability to PARP inhibitors. Small-molecule inhibition of mitochondrial respiration induced overproduction of the oncometabolite lactate, which acidified the extracellular milieu and repressed the expression of homologous recombination–associated DNA repair genes.

[Science Advances] To study the impact of mitochondrial dynamics on metastasis, scientists promoted mitochondrial elongation in metastatic breast cancer cells by individual genetic deletion of three key regulators of mitochondrial fission or by pharmacological intervention with leflunomide.