[FDA] The FDA approved cabozantinib for adult and pediatric patients 12 years of age and older with previously treated, unresectable, locally advanced or metastatic, well-differentiated pancreatic neuroendocrine tumors (pNET) and well-differentiated extra-pancreatic neuroendocrine tumors (epNET).

[Journal of Clinical Investigation] Scientists reported that plasma spermidine was correlated with the maturity of human newborns and reduced risk of inflammation. Administration of spermidine led to the remission of neonatal inflammation in mice.

[BMC Medicine] The phenotypic and metabolic properties of two subsets of exhausted CD8+ T cells were analyzed in both humans and NOD mice. T-cell receptor (TCR) diversity and Bulk RNA sequencing provided insights into the transcriptomic profiles and TCR reactivity of these cells.

[Cell Death & Disease] Researchers performed single-cell RNA-sequencing analysis and revealed a highly immunosuppressive high-grade serous ovarian carcinoma microenvironment, characterized by abundant infiltration of Tregs.

[Nature Medicine] In an evolving single-arm Phase II trial design, tumor-infiltrating lymphocytes were derived from and administered to 91 patients with treatment-refractory mismatch repair proficient metastatic gastrointestinal cancers in a schema with lymphodepleting chemotherapy and high-dose interleukin-2.

[Nature Communications] The authors proposed a one-time therapy through autologous transplantation of hematopoietic stem and progenitor cells genetically engineered ex vivo to produce both CCR5 knockout cells and long-term secretion of potent HIV-1 inhibiting antibodies from B cell progeny.

[Communications Biology] By combining the clinical samples, mucosal-associated invariant T (MAIT) deficiency mice and in vitro infected MAIT cell models, scientists found that pyroptosis was the main reason of MAIT cell loss in the peripheral blood of hemorrhagic fever with renal syndrome patients.

[Nature Communications] A panel of human antibodies targeting M1R and B6R was isolated from a human antibody library using phage display technology.

[Cancer Immunology Immunotherapy] Investigators examine the important role of vaccines in cancer therapy, focusing on recent advancements such as dendritic cell vaccines, mRNA vaccines, and viral vector-based approaches.

[The Doherty Institute] University of Melbourne’s Professor Laura Mackay has been presented with the National Health and Medical Research Council (NHMRC) Elizabeth Blackburn Investigator Grant Award for being the highest-ranking female applicant to receive an NHMRC Investigator Grant.

[Journal of Clinical Investigation] Researchers showed that a galactosylhydroxylysyl glucosyltransferase domain on lysyl hydroxylase 2-modified type-VI collagen to promote LUAD growth and metastasis.

[Journal of Experimental Medicine] The authors modeled heterogeneous tumors comprised of “hot” and “cold” tumor populations, giving rise to T cell–rich and T cell–poor tumors, respectively, and introduced fluorescent labels to enable precise spatial tracking.