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Extracellular Matrix News is an online resource that keeps scientists updated on the latest extracellular matrix research.
Multifaceted Roles of OCT4 in Tumor Microenvironment: Biology and Therapeutic Implications
[Leukemia] The authors review recent evidence showing that OCT4 expressed in cancer stem cells plays a multifaceted role in shaping the TME by interacting with the cellular TME components, including cancer-associated fibroblasts, tumor endothelial cells, tumor-infiltrating immune cells, as well as the non-cellular TME components, such as ECM.
THBS2-Producing Matrix CAFs Promote Colorectal Cancer Progression and Link to Poor Prognosis via the CD47-MAPK Axis
[Cell Reports] Employing single-cell RNA sequencing data of colorectal cancer (CRC), researchers identified a subset of matrix cancer-associated fibroblasts as a critical subtype that secretes THBS2, a molecule linked to advanced cancer stages and poor prognosis.
Snail1 As a Key Prognostic Biomarker of Cancer-Associated Fibroblasts in Breast Tumors
[Biochimica Et Biophysica Acta-Reviews On Cancer] The authors summarize recent findings from patient samples and mouse models of breast cancer, focusing on gene signatures identified by single-cell RNA sequencing that define cancer-associated fibroblast subtypes and predict cancer prognosis.
Fibromodulin Selectively Accelerates Myofibroblast Apoptosis in Cutaneous Wounds by Enhancing Interleukin 1β Signaling
[Nature Communications] Researchers found that fibromodulin induced myofibroblast apoptosis after wound closure to reduce scarring in small and large animal models.
SOX9-Dependent Fibrosis Drives Renal Function in Nephronophthisis
[EMBO Molecular Medicine] Researchers showed that kidney-specific deletion of Fbxw7, the recognition receptor of the SCFFBW7 E3 ubiquitin ligase, resulted in a juvenile-adult nephronophthisis-like pathology characterized by slow-progressing corticomedullary cysts, tubular degeneration, and gradual loss of kidney function.
Matrix Stiffness Regulates Traction Forces, Cytoskeletal Dynamics, and Collagen Reorganization in Trabecular Meshwork Cells in Glaucoma
[Matter] Researchers utilized a 2D in vitro cell culture model using a type I collagen network to replicate the ECM of the human trabecular meshwork in both normal and glaucomatous human eyes.
Role of Alpha-1 Antitrypsin in Bruch’s Membrane Integrity
[Scientific Reports] Investigators used genetic knockout mice to study the role of alpha-1 antitrypsin (AAT) in eye health. They showed that loss of AAT resulted in Bruch’s membrane thickening driven in part by increased laminin deposition with a concomitant decrease in collagen and elastin.
Collagen V Regulates Renal Function after Kidney Injury and Can Be Pharmacologically Targeted to Enhance Kidney Repair in Mice
[Science Translational Medicine] Using human population studies, the authors showed that circulating protein and renal mRNA amounts of collagen V A1 exhibited associations with kidney disease and incident chronic kidney disease risk.
Spatial Genomics: Mapping the Landscape of Fibrosis
[Science Translational Medicine] The authors review how various state-of-the-art spatial genomics approaches are being deployed to interrogate fibrosis across multiple organs, providing exciting insights into fibrotic disease pathogenesis.
Signaling Networks in Cancer Stromal Senescent Cells Establish Malignant Microenvironment
[Proceedings of The National Academy of Sciences of The United States of America] Investigators utilized p16-CreERT2-tdTomato mouse models to investigate the signaling networks established by senescent cancer stromal cells, contributing to the development of a malignant TME.
An Agrin–YAP/TAZ Rigidity Sensing Module Drives EGFR-Addicted Lung Tumorigenesis
[Advanced Science] Scientists revealed that epidermal growth factor receptor (EGFR) governed tumorigenic agrin expression and then sensitized the RTK to tumor-stiffness through integrin mechanosignaling.
FibroBiologics Unveils New and Expanded Houston Laboratory Space to Pursue Innovation and Breakthroughs in Fibroblast-Based Therapeutics
[FibroBiologics, Inc.] FibroBiologics, Inc. announced the opening of a new laboratory facility that will expand the company’s ability to pioneer additional candidates for chronic disease-focused indications leveraging its novel fibroblast-based technology.
The Extracellular Matrix News team is proud to provide an essential resource on the latest publications, reviews, industry news, and jobs relevant to the matrix research community. Topics include extracellular matrix-cell interactions, extracellular matrix protein characterization and their application in tissue engineering and regenerative medicine, and the development and characterization of synthetic scaffolds.
