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Immunology of Infectious Disease News
Immunology of Infectious Disease News is an online resource dedicated to covering the latest research and developments in the field of infectious diseases.
Abortive PDCoV Infection Triggers Wnt/β-catenin Pathway Activation, Enhancing Intestinal Stem Cell Self-Renewal, and Promoting Chicken Resistance
[Journal of Virology] Using chicken intestinal organoid monolayers, researchers found that although porcine deltacoronavirus infected them nearly as well as porcine intestinal organoid monolayers, infection did not result in detectable amounts of progeny virus.
Persistent Epigenetic Memory of SARS-CoV-2 mRNA Vaccination in Monocyte-Derived Macrophages
[Molecular Systems Biology] Researchers showed that SARS-CoV-2 mRNA vaccination significantly established histone H3 lysine 27 acetylation at promoters of human monocyte-derived macrophages, suggesting epigenetic memory.
Increased Frequency of Foxp3+CD8+ T Cells Are Associated with Disease Progression during HIV Infection
[Aids] Scientists investigated the role of Foxp3+CD8+ T cells during HIV infection and assessed the markers associated with CD4+ Tregs.
Increased Peripheral Interleukin-35 Suppresses CD4+T and CD8+ T-Cell Activity in Patients Living with Chronic Human Immunodeficiency Virus-1 Infection
[Viral Immunology] The authors investigated the role of the regulatory function of IL-35 to T-cell activity in patients living with chronic HIV-1 infection. 67 patients living with chronic HIV-1 infection and 17 controls were enrolled in the study.
Host Factor Naf1 Restricts HIV-1 Infection of Myeloid Cells and Compromises the Capacity of Dendritic Cell to Prime CD4+ T Cell
[Virologica Sinica] Investigators found that Naf1 had a higher expression in CD14+ monocytes than in monocyte-derived dendritic cells
Abortive PDCoV Infection Triggers Wnt/β-catenin Pathway Activation, Enhancing Intestinal Stem Cell Self-Renewal, and Promoting Chicken Resistance
[Journal of Virology] Using chicken intestinal organoid monolayers, researchers found that although porcine deltacoronavirus infected them nearly as well as porcine intestinal organoid monolayers, infection did not result in detectable amounts of progeny virus.
Borrelia burgdorferi Lacking All Cp32 Prophage Plasmids Retains Full Infectivity in Mice
[EMBO Reports] Researchers detailed the construction and infectivity of the first described B. burgdorferi strain lacking all cp32 plasmids.
Regulatory T Cells Constrain T Cells of Shared Specificity to Enforce Tolerance during Infection
[Science] Investigators used mouse models to investigate the role of regulatory T cells that recognized the same prostate tissue peptide antigen as conventional T cells.
Salmonella Effector SseL Induces PD-L1 Up-Regulation and T Cell Inactivation via β-catenin Signaling Axis
[Journal of Infectious Diseases] Researchers revealed that PD-L1 upregulation caused by Salmonella infection was mediated by Salmonella pathogenicity island 2 effectors, as PFA-fixed and STMΔssaV fail to alter PD-L1 levels.
METTL3 Plays Regulatory Roles in Acute Pneumonia during Staphylococcus aureus Infection
[ACS Infectious Diseases] The authors assessed the levels of N6-methyladenosine as well as the expression of methyltransferases (METTL3 and METTL14), demethylase fat mass and obesity-related protein, and methylation reader proteins YTHDF1 and YTHDF2 in mice and MH-S cells during S. aureus infection.
Jumbo Phage Killer Immune System Targets Early Infection of Nucleus-Forming Phages
[Cell] Scientists identified “jumbo phage killer”, a two-component immune system that terminates infection of ϕKZ-like phages, suppressing the expression of early phage genes and preventing phage DNA replication and phage nucleus assembly while saving the cell.
Staphylococcus aureus Uses a GGDEF Protein to Recruit Diacylglycerol Kinase to the Membrane for Lipid Recycling
[Proceedings of The National Academy of Sciences of The United States of America] Investigators showed that a membrane protein in Staphylococcus aureus called GdpS uses its cytosolic GGDEF domain to recruit DgkB to the membrane, orienting its active site to promote diacylglycerol kinase activity.
Immunology of Infectious Disease News was founded to keep the scientific community current with the latest developments in infectious disease research. We feature high-impact publications, news, jobs, and events focused on immune responses to and the development of treatments for infectious diseases such as COVID-19, HIV, hepatitis, tuberculosis, influenza, and malaria.
